X-box binding protein 1, also known as XBP1, is a protein which in humans is encoded by the XBP1 gene. [5] [6] The XBP1 gene is located on chromosome 22 while a closely related …

Mar 30, 2025 · XBP1 (X-Box Binding Protein 1) is a Protein Coding gene. Diseases associated with XBP1 include Major Affective Disorder 7 and Hematologic Cancer. Among its related …

As the most conserved signaling branch of UPR, the IRE1-XBP1 pathway plays an important role in both physiological and pathological states, and its activity has a profound impact on disease …

Jul 8, 2021 · The spliced form of X-box binding protein 1 (XBP1s) is an active transcription factor that plays a vital role in the unfolded protein response (UPR). Under endoplasmic reticulum …

XBP1 regulates the protumoral function of tumor-associated macrophages in human colorectal cancer. Elevated X-Box Binding Protein1 Splicing and Interleukin-17A Expression Are …

Oct 18, 2016 · The isoform encoded by the unspliced mRNA, XBP1 (U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1 (S), which shuts …

Feb 8, 2025 · The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off …

Feb 17, 2023 · XBP1 deficiency reduced tissue damage and cell apoptosis, protecting the mitochondria. Disruption of XBP1 was associated with reduced NLRP3 and cleaved caspase-1 …

Jul 2, 2020 · With this vignette, we will recap the events that led us to the discovery that the transcription factor XBP1 and a signaling pathway called the unfolded protein response (UPR) …

X-box binding protein 1 (XBP1) is a unique basic region leucine zipper (bZIP) transcription factor whose active form is generated by a nonconventional splicing reaction upon disruption of …