IHC analysis determines the level of HER2 protein expression and ISH, a cytogenetic technique, detects amplification of the HER2 (ERBB2) gene.1,2. Several FDA-approved HER2 IHC and ISH assays are commercially available to aid assessment of HER2.

HALO Breast IHC AI accurately detects tumour regions and tumour cells within breast cancer tissue and demonstrates high clinical agreement when scoring routine diagnostic IHC. This product can support pathologists by improving workflow efficiency and standardising results.

Visiopharm’s HER2 algorithm (APP) has a proven track-record of assisting pathologists by expediting review time during staging and identifying borderline cases which are immunohistochemistry (IHC) positive, ISH normal as having a HER2 score of 1+.

• Understand best practices in HER2 immunohistochemistry • Be able to implement optimal immunohistochemistry testing and scoring of staining for HER2 expression • Recognise the appropriate placement of therapies targeting HER2 alterations (including antibody-drug conjugates) across the patient journey in lung and ovarian cancers

Breast IHC AI is an automated, AI-based decision-support tool that standardizes scoring of HER2, ER, PR, and Ki67 IHC on whole slide images (WSI) in accordance with clinical scoring guidelines. It is seamlessly integrated into the HALO AP® diagnostic digital pathology platform.

Jan 3, 2023 · We examined the performance of a digitalized and artificial intelligence (AI)-assisted workflow for HER2 status determination in accordance with the American Society of Clinical Oncology (ASCO)/College of Pathologists (CAP) guidelines.

Ibex Breast HER2, an AI-powered decision support tool for pathologists, increases the precision and consistency of HER2 IHC scoring, including the highly subjective HER2-low cases, thereby enabling optimized treatment pathways and improved patient outcomes.

Here we present Breast IHC AI, a deep learning algorithm powered by Indica Labs, designed to improve efficiency and diagnostic accuracy through automating whole slide image (WSI) scoring of IHC stained breast cancer FFPE tissue sections.

Nov 1, 2013 · HER2 immunohistochemistry (IHC), FISH, and Dual ISH were performed on 101 breast cancer cases. Sixteen of 17 cases with 3+ HER2 by IHC showed gene amplification by FISH, and 15 showed amplification by Dual ISH. Three of the 2+ IHC cases were either amplified or equivocal by Dual ISH.

Dual-color in situ hybridization (Dual ISH) is fully automated, is viewable by bright-field microscopy, has a stable signal, and has separate colors for HER2 and chromosome 17 signals. HER2 immunohistochemistry (IHC), FISH, and Dual …