Nov 1, 2015 · We propose that Rac1-mediated phosphorylation of β-catenin stimulates Wnt-dependent gene transactivation by enhancing β-catenin-LEF-1 complex assembly, providing new insight into the mechanism of cross-talk between Rac1 and canonical Wnt/β-catenin signaling.

We propose that Rac1-mediated phosphorylation of β-catenin stimulates Wnt-dependent gene transactivation by enhancing β-catenin–LEF-1 complex assembly, providing new insight into the mechanism of cross-talk between Rac1 and canonical Wnt/β-catenin signaling. KEY WORDS: β-Catenin, Rac1, Wnt signaling, Proximity ligation assay

Apr 18, 2008 · Genetic ablation of Rac1 in the mouse embryonic limb bud ectoderm disrupts canonical Wnt signaling and phenocopies deletion of beta-catenin in causing severe truncations of the limb. Finally, Rac1 interacts genetically with …

Apr 20, 2021 · Nature Communications - RAC1 is a downstream target of the Wnt signaling that promotes intestinal stem cell expansion and tumorigenesis. Here, the authors identify the specific splice variant...

Our study demonstrates for the first time that beta-catenin-RAC1 cascade signals integrin-directed metastasis-associated tumor cell phenotypes in TNBC. Keywords: integrin-directed migration, RAC1 GTP-ase, brain-metastasis specific cells, actin cytoskeleton, Wnt pathway.

In contrast upon Wnt stimulation, active Rac1 induces the redistribution of Rac1/ β-catenin protein complex from the plasma membrane to the nucleus, favors the formation of β-catenin/LEF1 complex and potentiates the transactivation of Wnt responsive genes, via Jnk -induced β-catenin phosphorylation.

Apr 18, 2008 · Here we demonstrate that nuclear accumulation of β-catenin in response to Wnt requires Rac1 activation. The role of Rac1 depends on phosphorylation of β-catenin at Ser191 and Ser605, which is mediated by JNK2 kinase. Mutations of these residues significantly affect Wnt-induced β-catenin nuclear accumulation.

Nov 1, 2015 · We propose that Rac1-mediated phosphorylation of β-catenin stimulates Wnt-dependent gene transactivation by enhancing β-catenin–LEF-1 complex assembly, providing new insight into the mechanism of cross-talk between Rac1 and canonical Wnt/β-catenin signaling.

Nov 11, 2012 · A role for Rac1 GTPase in canonical Wnt signaling has recently been demonstrated, showing that it is required for β-catenin translocation to the nucleus. In this study, we investigated the mechanism of Rac1 stimulation by Wnt.

May 9, 2008 · Reporting in Cell, Fanxin Long and colleagues now show that, in response to Wnt, Rac1 activates Jun N-terminal kinase-2 (JNK2), which phosphorylates β-catenin and promotes its nuclear...