Feb 19, 2020 · Wnt/β-catenin signaling is essential for intestinal homeostasis and is aberrantly activated in most colorectal cancers (CRC) through mutation of the tumor suppressor Adenomatous Polyposis Coli...

Jan 3, 2022 · In this article, we comprehensively review the Wnt/β-catenin pathway from the above five aspects in combination with the latest research. Finally, we propose challenges and opportunities for...

APC, WNT signaling pathway regulator is a protein that in humans is encoded by the APC gene. [4] This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt …

Jul 19, 2023 · Here, we demonstrate the role of oncogenic APC in increasing plasma membrane free cholesterol and rigidity, thereby modulating Wnt signaling hubs. This results in an overactivation of Wnt...

Oct 17, 2017 · The tumor suppressor gene adenomatous polyposis coli (APC) is mutated in most colorectal cancers (CRCs), resulting in constitutive Wnt activation. To understand the Wnt-activating mechanism of the APC mutation, we applied CRISPR/Cas9 technology to engineer various APC-truncated isogenic lines.

Mutations in APC causing dysregulated Wnt signaling are the primary mechanism for hyperproliferation in CRC, where Wnt signaling is essential in intestinal stem cell maintenance.

Apr 2, 2025 · These biomarkers are involved in key regulatory steps of Wnt signaling and can help assess the tumor's responsiveness to Wnt-targeted therapies. Additionally, alterations in genes like APC, CTNNB1, and TCF/LEF transcription factors have been shown to correlate with varying degrees of Wnt pathway activation.

APC regulation of canonical WNT/beta-catenin signaling appeared active in the developing lens. In contrast, Apc controlled retinoic acid production via Rdh5 in the retina and was required for retinal differentiation.

Wnt growth factors activate a cascade of intracellular events, which is known as the canonical Wnt pathway that ultimately leads to the expression of a genetic program controlling the co‐ordinated expansion, fate and sorting of the epithelial cell population.

APC prevents constitutive activation of Wnt receptors in mammalian cells and Drosophila. APC loss results in ligand-independent pathway activation via clathrin-mediated endocytosis.