Lethal white syndrome (LWS), also called overo lethal white syndrome (OLWS), lethal white overo (LWO), and overo lethal white foal syndrome (OLWFS), is an autosomal genetic disorder most prevalent in the American Paint Horse.

Jun 9, 2020 · Lethal white overo (LWO) syndrome, also known as ileocolonic aganglionosis or aganglionic megacolon, is an autosomal recessive inherited disease primarily reported in Paint horses. Horses with a particular white spotting pattern known as frame overo can produce affected offspring.

OLWS is a genetic mutation that appears in horses with white markings, often frame overos. A foal must obtain two copies of the mutated gene to get the disease. The foals are born alive with blue eyes, pink skin and a white coat. These foals may …

Knowing the mutations and changes in cellular DNA that cause the various coat patterns and colors, and their associated diseases, like Overo Lethal White Syndrome, helps horse breeders make informed and ethical breeding choices.

Apr 7, 2025 · A congenital abnormality most commonly associated with frame overo American Paint horses is termed overo lethal white foal syndrome, lethal white foal syndrome (LWFS), or lethal white overo syndrom...

Aug 21, 2024 · The white foal, on the other hand, is born with a white coat, pink skin, brown or blue eyes, and does not change colour as it ages. In effect, the white appearance is causes by multiple overlapping white patterns that do not leave any of the base coat colour showing.

Sep 28, 2011 · Overo lethal white syndrome occurs in white foals born to paint horses but must be differentiated from other causes of neonatal colic. from the sacral region of the spinal cord and the occipi-tal region of the brain invade the gut wall, other internal organs, and blood vessels.

Nov 1, 2001 · Lethal white foals have two copies of the defective allele (two alleles make up a gene, one from each parent), while their healthy carrier parents have one, and non-carrier horses have none....

Overo lethal white foal syndrome (OLWS) is a fatal autosomal recessive trait disorder that affects newborn foals bred that receive a copy of the mutated OLW gene from each parent.

Feb 18, 2018 · Some white foals are born with a genetic mutation that causes them to die within days. Here is what you need to know.