Oct 7, 2022 · In this paper, we briefly introduce the molecular mechanism of m 6 A modification. Then, we focus on WTAP, a component of the m 6 A methyltransferase complex, and …

Oct 3, 2023 · Here, we show that the METTL3–METTL14 complex possesses promiscuous DNA-binding activity, which disrupts its ability of RNA methylation. Moreover, WTAP–VIRMA …

Given the direct interaction between WTAP and METTL3, we speculated that WTAP may serve to regulate m6A methyltransferase activity in vivo. To test this hypothesis, we examined the m6A …

Here, we found that high levels of m 6 A modification in a variety of hyperinflammatory states are p65-dependent because Wilms tumor 1–associated protein (WTAP), a key component of the …

Mar 4, 2025 · Wilms’ tumor 1-associated protein (WTAP) is a key N6-methyladenosine (m 6 A) methyltransferase that is upregulated in t (8;21) acute myeloid leukemia (AML) under hypoxia …

May 16, 2024 · Mechanistically, upregulated WTAP is more prone to phase separation to facilitate the aggregation of the writer complex to nuclear speckles and the deposition of m6A marks on …

Here, we demonstrate that the METTL3/METTL14/WTAP m 6 A methyltransferase complex (MTC) is localized to many promoters and enhancers and deposits the m 6 A modification on …

Jan 17, 2024 · WTAP (m6A methyltransferase) is a protein associated with XIST, and RBM15/15B can, also bind METTL3 through WTAP protein to form m6A methylase complex …

WTAP-mediated m6A modification on circCMTM3 inhibits hepatocellular carcinoma ferroptosis by recruiting IGF2BP1 to increase PARK7 stability. Digest Liver Dis. 2023;55:967–81. doi: …

Aug 22, 2019 · WTAP-guided m6A modification contributes to the progression of HCC via the HuR-ETS1-p21/p27 axis. Our study is the first to report that WTAP-mediated m6A methylation …