Mar 3, 2020 · Non-small cell lung cancer (NSCLC) represents a difficult condition to treat, due to epidermal growth factor receptor (EGFR) kinase domain mutations, which lead to ligand-independent phosphorylation.

WT1-mediated apoptosis was associated with reduced synthesis of the epidermal growth factor receptor (EGFR), but not of other postulated WT1-target genes, and it was abrogated by constitutive expression of EGFR.

Mar 2, 2022 · Osteosarcoma cell lines expressing WT1 under an inducible tetracycline-regulated promoter mediate apoptosis through reduced synthesis of the EGFR . Also, WT1 can negatively regulate growth factor receptors such as EGFR and the insulin receptor, repressing survival signals and promoting death .

Oct 2, 1995 · WT1-mediated apoptosis was associated with reduced synthesis of the epidermal growth factor receptor (EGFR), but not of other postulated WT1-target genes, and it was abrogated by constitutive expression of EGFR.

Our results indicated that WT1 is involved in expressional regulation of the EGFR family members and ER-α during development of acquired tamoxifen resistance. Keywords: WT1, HER2, EGFR, estrogen and antiestrogen, breast cancer.

In this study, we report that the Wilms' tumor gene product WT1, a zinc finger transcription factor, is able to enhance the activity of the rat EGFR promoter in cotransfection assays. Gel mobility shift assays demonstrate that WT1 binds to the TCC repeat sequences of the rat EGFR promoter.

Mar 15, 2007 · The Wilms' tumor 1 (WT1) gene encodes a transcription factor important for normal cellular development and cell survival.

These results strongly suggested that WT1 expression induces the enhanced expression of EGFR and HER2, sustained activation of the MAPK/ERK signaling and increased expression of cyclin D1 and c-Myc observed in MCF7 H cells.

Among PDSTFs in urinary exosomes, Wilms tumor 1 (WT1) levels reflected damage of diabetic glomeruli in the patients. Urinary exosomal WT1 can predict the decline in eGFR for the following several years.

Mar 27, 2013 · We found that the level of exosomal WT1 were associated with a significant increase in urine protein-to-creatinine ratio, albumin-to-creatinine ratio, and serum creatinine as well as a decline in eGFR.