Sep 15, 2021 · Wolframin-1–expressing (Wfs1 +) pyramidal neurons have been shown functionally to modulate hippocampal CA1 neurons in mice. Here, we report that Wfs1 + pyramidal neurons are conserved in the ECII of postmortem human brain tissue and that Wfs1 colocalized with abnormally phosphorylated tau in brains from individuals with early AD.

The WFS1 gene was first identified in Wolfram Syndrome 1 (WS1), a rare autosomal recessive genetic disorder characterized by severe and progressive neurodegenerative changes. WFS1’s role in various cellular mechanisms, particularly in calcium ...

In this review, we focus on the function of WFS1 and WFS2 in the central nervous system as well as their implications in WS and AD. We also propose three future directions for elucidating the role of WFS1 and WFS2 in WS and AD.

Sep 15, 2021 · Wolframin-1–expressing (Wfs1 +) pyramidal neurons have been shown functionally to modulate hippocampal CA1 neurons in mice. Here, we report that Wfs1 + pyramidal neurons are conserved in the ECII of postmortem human brain tissue and that Wfs1 colocalized with abnormally phosphorylated tau in brains from individuals with early AD.

Sep 17, 2021 · Does the spread of misfolded tau influence synaptic signaling between EC Wfs1+ neurons and hippocampal CA1 neurons? The researchers brought a three-prong approach to this question, using optogenetic, chemogenic, and electrophysiological methods to test how tau affected the road on which it traveled.

Autosomal recessive mutations in the WFS1 gene will underlie Wolfram syndrome 1 (WS1), a rare and severe neurodegenerative disease characterized by diabetes insipidus, diabetes mellitus, optic atrophy, deafness, and other neurological, urological and psychiatric abnormalities.

Jan 20, 2016 · Using next-generation RNA sequencing, Cembrowski et al. show that CA1 pyramidal cells (CA1 PCs) exhibit marked variability across the long hippocampal axis. This heterogeneity emerges from a spectrum of gene-expression gradients, producing a highly variable continuum of CA1 PCs.

Sep 15, 2021 · Wolframin-1–expressing (Wfs1+) pyramidal neurons have been shown functionally to modulate hippocampal CA1 neurons in mice. Here, we report that Wfs1+ pyramidal neurons are conserved in the...

Dec 7, 2020 · Recently we found excitatory neurons expressing the Wolframin (WFS1) in the entorhinal cortex and the CA1 of hippocampus are particularly vulnerable to pathological tau in tau transgenic mice and human AD. However, the role of WFS1 in mediating this selective neuronal vulnerability is unknown.

Aug 20, 2008 · Prominent Wfs1 expression was seen in the hippocampal CA1 region, parasubiculum, superficial part of the second and third layers of the prefrontal cortex and proisocortical areas, hypothalamic magnocellular neurosecretory system, and …