Mar 30, 2025 · VPS4A (Vacuolar Protein Sorting 4 Homolog A) is a Protein Coding gene. Diseases associated with VPS4A include Cimdag Syndrome and Protein-Deficiency Anemia. …

Vacuolar protein sorting-associated protein 4A is a protein that in humans is encoded by the VPS4A gene. [5][6][7] The protein encoded by this gene is a member of the AAA protein family …

Feb 8, 2025 · Vps4A regulates the plasma membrane localization and exosome sorting of beta-catenin, consequently decreasing beta-catenin signaling, and thereby inhibiting epithelial …

Apr 30, 2024 · Mutations in the human AAA-ATPase VPS4 isoform, VPS4A, cause severe neurodevelopmental defects and congenital dyserythropoietic anemia (CDA).

Phosphorylated VPS4A tethers LDs to LC3, facilitating selective lipophagy. VPS4A levels correlate inversely with lipophagy in human metabolic-dysfunction-associated steatotic liver …

We observed downregulation of VPS4B mRNA and protein levels from CRC patient samples. We identified VPS4A paralog as a synthetic lethal interactor for VPS4B in vitro and in mouse …

Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in …

Jan 4, 2025 · Gene target information for VPS4A - vacuolar protein sorting 4 homolog A (human). Find diseases associated with this biological target and compounds tested against it in …

Mar 23, 2010 · Here we show that purified human VPS4A is essentially inactive but can be stimulated to hydrolyze ATP by ESCRT-III proteins in a reaction that requires both their …

Nov 13, 2019 · Three unrelated patients with dyserythropoiesis, hemolytic anemia, and neurodevelopmental delay were found to have missense mutations in the gene VPS4A which …