Some experimental and clinical studies have demonstrated two main mechanisms leading to VILI: direct trauma to the cell, which promotes releasing of cytokines to the alveolar space as well as to the systemic circulation and also, the so-called ‘mechanotransduction’ mechanism.

Jan 22, 2025 · VILI, or ventilator-induced lung injury, refers to lung damage that occurs as a result of mechanical ventilation. This injury arises when the mechanical forces applied during ventilation—such as excessive pressure, large tidal volumes, or high oxygen concentrations—compromise lung tissue integrity.

Oct 20, 2023 · Our study found that rutin improved VILI through inhibiting NLRP3 inflammasome activation in vivo. However, whether rutin could decrease mechanical stretch induced cellular injury in vitro is still unclear. In addition, whether rutin directly contributes to protective effect on pulmonary epithelial cell in VILI remains unclear.

Ventilator-induced lung injury (VILI) is a serious acute injury to the lung tissue that can develop during mechanical ventilation of patients. Due to the mechanical strain of ventilation, damage can occur in the bronchiolar and alveolar epithelium ...

Sep 1, 2015 · VILI is the result of a complex interplay among various mechanical forces that act on lung structures, such as type I and II epithelial cells, endothelial cells, macrophages, peripheral airways, and the extracellular matrix (ECM), during mechanical ventilation.

Jun 29, 2018 · Mechanical ventilation applies physical stresses to the tissues of the lung and thus may give rise to ventilator-induced lung injury (VILI), particular in patients with acute respiratory distress syndrome (ARDS). The most dire consequences of VILI result from injury to …

Apr 1, 2017 · The pathobiology of VILI and ARDS shares many inflammatory features including increases in lung vascular permeability due to loss of endothelial cell barrier integrity resulting in alveolar flooding.

Nov 27, 2023 · This narrative review discusses the advantages and limitations of experimental VILI, elucidates the mechanisms underlying the pathogenesis, progression, and resolution of VILI, and analyzes the strategies that can mitigate VILI.

Mar 28, 2013 · In this review, we will review the pathophysiology of VILI, discuss a number of novel physiological approaches for minimizing VILI, therapies to counteract biotrauma, and highlight a number of experimental studies to support these concepts.

Mar 31, 2023 · We developed a computational model of VILI progression and recovery based on dynamic biophysical processes that interact across cell and organ level scales. At the level of the airway epithelial cell, biofluid mechanical stresses are hypothesized to destroy cell adhesion complexes in a stochastic manner, while spontaneous reassembly of these ...