A seminal discovery shaping our current understanding of VILI occurred in the mid-1980s, when the first CT scans of patients with ARDS revealed strikingly heterogeneous lung parenchyma.

Jun 26, 2015 · The purpose of this article is to present an approach to VILI pathophysiology focused on the effects of volutrauma that lead to lung injury and the 'mechanotransduction' …

Jul 5, 2024 · Ventilator induced lung injury (VILI) is sometimes used as a synonym for VALI, but strictly speaking VILI is VALI when mechanical ventilation is the proven cause of lung injury

Aug 7, 2022 · A hallmark of ARDS is progressive shrinking of the ‘baby lung,’ now referred to as the ventilator-induced lung injury (VILI) ‘vortex.’ Reducing the risk of the VILI vortex is the goal …

This injury is called ventilator-induced lung injury (VILI) and can result in pulmonary edema, barotrauma, and worsening hypoxemia that can prolong mechanical ventilation, lead to multi …

Jun 29, 2018 · Mechanical ventilation applies physical stresses to the tissues of the lung and thus may give rise to ventilator-induced lung injury (VILI), particular in patients with acute …

Jan 22, 2025 · VILI can exacerbate pre-existing lung conditions or create new lung pathologies, leading to complications such as acute respiratory distress syndrome (ARDS). Understanding …

Nov 28, 2013 · Regional lung overdistention is a key factor in generating ventilator-induced lung injury. Since there is no well-accepted clinical method of measuring regional overdistention, …

For mechanically ventilated patients with ARDS at greatest risk of VILI, one recent multicenter trial suggested neuromuscular blockade for 48 hours improved survival in patients with …

Jan 28, 2014 · Supraphysiologic V t ventilation induces ventilator-induced lung injury (VILI) in adults. There is a lack of data from randomized, controlled clinical trials addressing the …