Proto-oncogene vav is a protein that in humans is encoded by the VAV1 gene. [5] The protein encoded by this proto-oncogene is a member of the Dbl family of guanine nucleotide exchange factors (GEF) for the Rho family of GTP binding proteins. The protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation.

Jul 25, 2024 · The guanine nucleotide exchange factor (GEF) VAV1, a previously ‘undruggable’ protein integral to T/B lymphocyte antigen–receptor signaling, promotes actin polymerization, immunological synapse formation, T cell activation and differentiation, and cytokine production.

Vav1 is a 95-kDa protein expressed in all hemopoietic cells that becomes rapidly tyrosine phosphorylated following T cell antigen receptor (TCR) stimulation. Vav1 contains multiple domains characteristic of signal transducing proteins, including a Dbl homology domain, a hallmark of a guanine nucleot …

Mar 30, 2025 · Complete information for VAV1 gene (Protein Coding), Vav Guanine Nucleotide Exchange Factor 1, including: function, proteins, disorders, pathways, orthologs, and expression.

Using experimental autoimmune encephalomyelitis, an animal model of MS, Jagodic et al. have focused on a region of the rat genome on chromosome 9 that encodes the gene Vav1.

Jan 22, 2010 · We report the structure and biophysical and cellular analyses of the five-domain autoinhibitory element of Vav1. The catalytic Dbl homology (DH) domain of Vav1 is controlled by two energetically coupled processes.

Vav1 Promotes B-Cell Lymphoma Development. Regulatory interplay between Vav1, Syk and beta-catenin occurs in lung cancer cells. Identification of molecular subtyping system and four-gene prognostic signature with immune-related genes for uveal melanoma.

Apr 27, 2023 · VAV1 is a hematopoietic signal transducer that possesses a GDP/GTP nucleotide exchange factor (GEF) that is tightly regulated by tyrosine phosphorylation, along with adapter protein domains, such as SH2 and SH3.

Oct 8, 2018 · Vav1 is physiologically active as a GDP/GTP nucleotide exchange factor (GEF) in the hematopoietic system. Overexpression of Vav1 in multiple tumor types is known to enhance oncogenicity, yet...

The guanine nucleotide exchange factor (GEF) VAV1, a previously 'undruggable' protein integral to T/B lymphocyte antigen-receptor signaling, promotes actin polymerization, immunological synapse formation, T cell activation and differentiation, and cytokine production.