Jul 1, 2021 · Vacuolization of myeloid and erythroid precursors in the bone marrow (BM) has been recently identified as a hallmark feature of a new adult-onset inflammatory syndrome called VEXAS (vacuoles, E1 enzyme, X linked, autoinflammatory, somatic).

Toxic vacuolation, also known as toxic vacuolization, [1] is the formation of vacuoles in the cytoplasm of neutrophils in response to severe infections or inflammatory conditions. [2][3] Toxic vacuolation is associated with sepsis, particularly when accompanied by toxic granulation. [4] .

Oct 1, 1998 · We reviewed 148 cases in which vacuolated neutrophils were recognized on examination of peripheral blood smears by the medical technologist and confirmed by the pathologist. There was a high correlation between the presence of vacuolated neutrophils and one or more positive microbiologic cultures.

Vacuoles in abnormal white blood cells appear as clear, round, or oval spaces within the cytoplasm. They lack the staining properties of normal cellular components and typically appear empty or light blue due to the presence of fluid in the abnormal white blood cells.

The frequency of occurrence of vacuoles in red blood cells was studied by transmission electron microscopy. Small vacuoles were found in about 13% of the cell sections, and they had a mean diameter of 130 +/- 72 nm (mean +/- SD).

EDTA storage may produce degenerative vacuolization; vacuoles typically few in number and not associated with toxic granulation or Döhle bodies. Seen in conditions associated with increase cytokine release such as infection, burns, trauma, and G-CSF.

Cytoplasmic vacuolations are sometimes frequently seen in blood cells on peripheral smear but are often ignored. Presence of such vacuolations can be seen in red blood cells (RBCs) and WBCs (neutrophils, lymphocytes and monocytes). These vacuolations can be true or artefactual.

Jul 1, 2021 · VEXAS syndrome (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) is a monogenic disease of adulthood caused by somatic mutations in UBA1 in hematopoietic progenitor cells.

2 days ago · VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome is a paradigm of an acquired, severe autoinflammatory and hematological disease of aging caused by clonal dominance 17.

Nov 19, 2020 · The peripheral blood smear revealed vacuoles in neutrophils and monocytes consistent with Jordans’ anomaly (Figures 1c-1f). Serum lipid analysis showed elevated serum triglyceride of 257 mg/dL (normal range: 0-149) and very-low-density lipoprotein cholesterol of 51 mg/dL (normal: 10-40).