Jan 15, 2000 · von Willebrand factor (vWF), a glycoprotein produced uniquely by endothelial cells and megakaryocytes, is routinely used to identify vessels in tissue sections. Vessel density in tumor specimens, as determined by immuno-histochemical staining for vWF or other endothelial cell markers, is a negative …

4 days ago · Definition / general | Interpretation | Positive staining - normal | Positive staining - disease | Additional references

VWF expression was also demonstrated by immunofluorescence staining in SAOS2 and a representative patient derived malignant glioma cell line M049, but not in KHOS (Figure 1C). These results demonstrated that some cancer cells of non-endothelial origin express VWF at the RNA and protein levels.

von Willebrand factor (VWF) plays key roles in both primary and secondary hemostasis by capturing platelets and chaperoning clotting factor VIII, respectively. It is stored within the Weibel–Palade bodies (WPBs) of endothelial cells as a highly ...

Dec 7, 2017 · The diagnosis of von Willebrand disease is complex and includes the assay of VWF antigen (VWF:Ag), VWF platelet binding activity (VWF:RCo or VWF:GPIbM), and factor VIII activity.

These findings highlight that in situ vWF antibody staining should not be used as evidence of endothelial to mesenchymal transition and, more generally, that caution is warranted when inferring cellular lineage from canonical marker expression.

Jan 25, 2019 · Expression and cellular localization of (B) von Willebrand factor (VWF) and (C) VE-cadherin determined by immunofluorescent staining with corresponding antibodies (magnification ×200).

Definition: Von Willebrand factor (VWF) is a large multimeric glycoprotein produced in endothelial cells and megakaryocytes and present in subendothelial matrix, blood plasma and platelets. VWF mediates adhesion and aggregation of platelets at sites of vascular injury, which are critical for both haemostasis and thrombosis.

Mar 21, 2017 · Von Willebrand factor (vWF) staining (arrows) was present in the endothelium of large blood vessel (BV), but was minimal in alveolar septa (S) in sections from the control foal lung (A and C).

The aim of the research was to set the optical density quantitative parameters of the von Willebrand factor immunohistochemical staining (vWF) in the endothelium and fibrinoid of the placenta during the secundines inflammation concomitant with iron deficiency anemia in gravidas. The total number of 198 placentas was studied.