Von Willebrand factor (VWF) (German: [fɔn ˈvɪləbʁant]) is a blood glycoprotein that promotes primary hemostasis, specifically, platelet adhesion.

The main things found in Weibel-Palade bodies are von Willebrand factor (described above) and P-selectin (a cell-adhesion molecule that endothelial cells use to catch passing leukocytes, allowing them to leave the blood vessel and migrate into the surrounding tissue).

Mar 26, 2015 · In this review, an update on our current knowledge on VWF biosynthesis, secretion, and clearance is provided and we will discuss how they can be affected by the presence of protein defects.

Sep 1, 1998 · Von Willebrand factor (vWF), a large glycoprotein encoded by a gene on chromosome 12, is synthesized by vascular endothelial cells and circulates in human plasma at concentrations of 10 μg/mL. 1 In plasma, vWF forms a noncovalent complex with coagulation factor VIII, the protein encoded by a gene on the X chromosome that is deficient or ...

Jan 7, 2021 · von Willebrand factor is a useful biomarker for liver fibrosis and prediction of hepatocellular carcinoma development in patients with hepatitis B and C.

Similarly, VWF function is influenced by the source of release (endothelial vs platelet), ADAMTS13 degradation, shear stress, and mutations and variants that affect the interaction between VWF and its many binding partners.

Feb 5, 2025 · Using endothelialized fluidic devices, we show that aberrant flow patterns that may occur in venous valve pockets of individuals with common stasis-related risk factors can cause the formation of von Willebrand factor–platelet tangles that are resistant to ADAMTS13 removal.

Von Willebrand factor (VWF) works by mediating the adherence of platelets to one another and to sites of vascular damage. VWF binds to a protein complex made up of the glycoproteins Ib, IX, and V on the surfaces of platelets.

von Willebrand factor (VWF) is an adhesive and multimeric glycoprotein that found its historical origin in 1924, when the Finnish physician Erik von Willebrand first reported a family with a serious hereditary bleeding affecting consanguineous families 1. The proband was a five years old girl with severe bleeding since birth.

von Willebrand factor (VWF) plays a critical role in primary hemostasis following vascular injury by tethering platelets to exposed collagen. Here, VWF binding to macrophages is shown to trigger NF-κB activation and induce pro-inflammatory responses.