In the present study, we re-annotated von Willebrand factor (VWF), assigned its entire sequence to specific modules, and related these modules to structure using electron microscopy (EM). …

Von Willebrand disease type 2 is characterized by qualitative deficiency and functional anomalies of von Willebrand factor. It is divided in different subtypes including 2A, 2B, 2M and 2N …

Apr 5, 2011 · The D1 and D2 domains of the VWF propeptide contain CXXC sequence (Cys159-Gly-Leu-Cys162 and Cys521-Gly-Leu-Cys524), which resembles the functional site of thiol …

Sep 19, 2019 · Bonthron et al. (1986) presented the nucleotide sequence of pre-pro-von Willebrand factor cDNA. Lynch et al. (1985) also cloned the VWF gene, and Lynch et al. …

Jun 2, 2022 · Sequential stacking of these homodimers leads to a right-hand helical tubule for VWF storage. The clinically identified VWF mutations in the propeptide disrupted different …

Von Willebrand factor (vWF) is an adhesive, multimeric glycoprotein present in plasma, platelets, and subendothelium, which has two main functions: (1) it serves as a carrier for factor VIII and …

Jul 25, 2013 · Since the first sequence analysis of the gene in 1989, VWF has been recognized as having a high rate of sequence variation between individuals. Next-generation DNA …

Jul 12, 2012 · In the present study, we re-annotated von Willebrand factor (VWF), assigned its entire sequence to specific modules, and related these modules to structure using electron …

Feb 25, 2025 · Sequence analysis of the VWF gene is relatively simple to perform but is complicated by the presence of a partial VWF pseudogene [exons 23-34] on chromosome 22. …

F8VWF, VWD. Chromosome 12: 6,058,040-6,233,936 reverse strand. GRCh37:CM000674.1. This gene has 8 transcripts (splice variants), 10 paralogues and is associated with 9 …