Discovery of an unconventional lamprey lymphocyte lineage …
Sep 3, 2024 · Diverse VLRB genes encode secretory antigen-specific agglutinins and are only expressed by B-like lymphocytes, which are equivalent to B cells in jawed vertebrates 6. The …
Evolution and diversification of lamprey antigen receptors: …
Apr 29, 2007 · In the lamprey genome, we identify here about 850 distinct cassettes encoding leucine-rich repeat modules that serve as sequence templates for the hypervariable VLR …
Somatic diversification of variable lymphocyte receptors in the ...
Jul 8, 2004 · Our search for the phylogenetic roots of adaptive immunity in the lamprey has instead identified a new type of variable lymphocyte receptors (VLRs) composed of highly …
Evolution of two distinct variable lymphocyte receptors in …
Aug 29, 2023 · Jawless vertebrates possess an alternative adaptive immune system in which antigens are recognized by variable lymphocyte receptors (VLRs) generated by combinatorial …
Diversity and Function of Adaptive Immune Receptors in a
Dec 23, 2005 · In the lamprey, a single incomplete germline VLR gene generates a diverse repertoire of cell surface receptors through somatic rearrangement of LRR cassettes that flank …
Antigen Recognition by Variable Lymphocyte Receptors | Science
Sep 26, 2008 · Variable lymphocyte receptors (VLRs) rather than antibodies play the primary role in recognition of antigens in the adaptive immune system of jawless vertebrates. Combinatorial …
Evolution of variable lymphocyte receptor B antibody loci in …
Dec 9, 2021 · Three types of variable lymphocyte receptor (VLR) genes, VLRA, VLRB, and VLRC, encode antigen recognition receptors in the extant jawless vertebrates, lampreys and hagfish. …
To increase the repertoire of targetable tumor cell antigens we utilized the immune system of the sea lamprey to generate directed variable lymphocyte recep-tors (VLRs). VLRs serve as …
Genetic engineering of chimeric antigen receptors using lamprey …
To increase the repertoire of targetable tumor cell antigens we utilized the immune system of the sea lamprey to generate directed variable lymphocyte receptors (VLRs). VLRs serve as …
Dual nature of the adaptive immune system in lampreys | Nature
May 27, 2009 · Distinctive gene expression profiles for VLRA+ and VLRB+ lymphocytes in lampreys are now shown to resemble those of mammalian T and B cells, offering insight into …
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