VLA-4 can be found on hematopoietic stem and progenitor cells. These cells are found in the bone marrow, as that is where they are produced, and throughout the rest of the body. VLA-4, …

VLA-4 is a member of the integrin family that can bind to vascular cellular adhesion molecule 1 (VCAM-1). Its ligation enhances TCR-mediated T cell proliferation by strengthening the signal …

VLA-4 (very late antigen 4, 3 α 4 β 1-integrin, CD49d/CD29) plays a major role in the regulation of immune cell recruitment to inflamed endothelia and sites of inflammation.

Aug 14, 2024 · We report that the BCR is also able to effectively inside–out activate the VLA-4 integrin in circulating CD49d-expressing CLL cells through an autonomous antigen …

Mar 23, 2020 · Here, we review the contribution of VLA-4 to normal B cell differentiation on the one hand, and to the pathophysiology of B cell malignancies on the other hand. We describe …

Feb 6, 2025 · We evaluate VLA-4 (integrin α4β1) as a potential target for RPT in solid tumors using radiolabeled copper-64 ( [64Cu]Cu-) and copper-67 ( [67Cu]Cu-CB-TE1A1P-PEG4 …

Feb 9, 2021 · In this respect, a humanized IgG4 anti-VLA-4 monoclonal antibody (specific to the α4-integrin chain of VLA-4) has been successfully applied to treat multiple sclerosis as well as …

Jul 1, 2009 · Using dynamic fluorescence resonance energy transfer (FRET) analysis of a novel VLA-4 FRET sensor under total internal reflection fluorescence (TIRF) microscopy, we show …

VLA-4 mediates shear resistant adhesion of human melanoma cells to the BBB. So far, we have shown the important role of VLA-4 for mouse B16F10 melanoma cell shear resistant adhesion …

Mar 23, 2020 · Integrins such as the integrin very late antigen-4 (VLA-4; CD49d/CD29) control the localization of healthy as well as malignant B cells within the tissue, and thus determine the …