The repertoire of human germline VH segments reveals about fifty groups of VH segments with different hypervariable loops. J. Mol. Biol., 227, 776-798. 35. van Es, J. H., Heutink, M., …

Dec 20, 2016 · Validated immunoglobulin variable (V) gene databases are close to completion only for human and mouse. We present a novel computational approach, IgDiscover, that …

In this study, we constructed a large naïve human Fab library, obtained a database of unique 7,373 VH and 41,804 VK sequences by 454 pyrosequencing, and thoroughly determined the …

We report in this paper the first analysis of the expression pattern of Ig VH and VK families in human adult normal peripheral B lymphocytes, by in situ hybridization using specific VH1 to …

Jan 15, 1990 · The VH and VL regions of the A48RI+, VHX24-Vk 10+ mAb showed low to moderate levels of somatic mutation which showed different patterns of distribution between …

Sep 1, 1991 · We have examined how many different H chain variable (VH) and kappa-chain variable (Vk) germ-line genes are used in the antibody response to the influenza virus …

subunits (e.g., VH/Vk paired with CH1/Cλ or T cell receptor Ca/Cb), the major role of the constant domains for both k- and λ-containing Fabs may be to reduce the hydrophobic exposure at the …

Sep 1, 1990 · We report in this paper the first analysis of the expression pattern of Ig V H and V K families in human adult normal peripheral B lymphocytes, by in situ hybridization using specific …

V BASE also provides scale maps for the VH, VK, VL and D regions. These denote the positions of all the functional and non-functional segments together with the locations (and frequencies) …

The immunoglobulin heavy- and light-chain variable region (VH and VK) genes were isolated from 8E5 hybridoma cells, which secreted monoclonal antibody against human fibrin by RT-PCR. …