Dec 1, 2018 · In this investigation, we reported combination immunotherapy targeting the angiogenesis factors VEGF and PIGF for breast cancer, aiming for the simultaneous depletion of VEGF and PIGF via RNAi in M2-TAMs and tumor cells.

Oct 22, 2022 · Ate-Grab exerts anti-tumor and anti-fibrotic effects in PDAC models via the PD-L1-directed PlGF/VEGF blockade. Furthermore, Ate-Grab synergizes with gemcitabine by relieving desmoplasia.

VEGF-A binds with high affinity to two VEGF receptor tyrosine kinases (VEGFR1, VEGFR2) and with lower affinity to co-receptors called neuropilin-1 and neuropilin-2 (NRP1, NRP2). Here, we use a structural viewpoint to summarise our current knowledge of VEGF-VEGFR activation and signal transduction.

VEGF-A, VEGF-B, and PIGF binds VEGFR1 primarily localized on blood vascular endothelial cells. VEGFR2 is expressed on both blood vascular and growing lymphatic vessels, and VEGF-A and processed VEGF-C/VEGF-D are ligands for this receptor.

Given that vascular endothelial growth factor (VEGF) and placental growth factor (PIGF), over-expressed in breast cancer cells and M2-like tumor-associated macrophages (M2-TAMs) within tumor microenvironment (TME), work synergistically and independently in mediating tumor progression and immunosuppr …

PIGF is a ligand for VEGFR-1, which has been reported to play a dual role in cancer as a stimulator of angiogenesis and as an autocrine or paracrine factor promoting proliferation of tumor cells expressing VEGFR-11 [23], [24].

Oct 14, 1994 · The recently identified placenta growth factor (PIGF) is a member of the vascular endothelial growth factor (VEGF) family of growth factors. PIGF displays a 53% identity with the platelet-derived growth factor-like region of VEGF.

The recently identified placenta growth factor (PIGF) is a member of the vascular endothelial growth factor (VEGF) family of growth factors. PIGF displays a 53% identity with the platelet-derived growth factor-like region of VEGF.

Dec 1, 2017 · The human placenta expresses the pro-angiogenic/pro-permeability VEGF-A 165 a, anti-angiogenic VEGF-A 165 b, placental growth factor (PIGF) and their receptors, VEGFR2 (KDR), VEGFR1 (Flt-1), neuropilin-1 and soluble Flt-1 (sFlt-1).

Dec 26, 2017 · The human VEGF family consists of 5 related glycoproteins: VEGFA, VEGFB, VEGFC, VEGFD, and PIGF (placental growth factor). These are secreted to form homodimers, which interact with a family of 3 receptor tyrosine kinases: VEGFR1 (VEGF receptor 1), VEGFR2, and VEGFR3 (Figure 1).