V(D)J recombination (variable–diversity–joining rearrangement) is the mechanism of somatic recombination that occurs only in developing lymphocytes during the early stages of T and B …

Recent genomewide analyses of lymphoid neoplasms have revealed V(D)J recombination-driven oncogenic events, and have intensified interest in the regulatory mechanisms responsible for …

Apr 19, 2002 · V(D)J recombination is of fundamental importance to the generation of diverse antigen receptor repertoires. We review our current understanding of the V(D)J recombination …

V(D)J recombination is an essential mechanism of the adaptive immune system, producing a diverse set of antigen receptors in developing lymphocytes via regulated double strand DNA …

Jul 11, 2018 · In this article, I will explain to you the structure of the antibody, the mechanism of VDJ recombination and the concept of antibody diversity. The present article will help you …

Feb 8, 2025 · Explore the complex process of VDJ recombination, highlighting its role in immune diversity and the genetic mechanisms involved.

In this review, we summarize the major progress in mechanism studies of immunoglobulin V(D)J gene recombination and CSR as well as SHM, and their regulatory mechanisms. Keywords: B …

V(D)J recombination is a site-specific recombination reaction that occurs specifically in developing oocytes of vertebrates and plays a part in generating their vast repertoire of immunoglobulins …

V(D)J recombination undergoes regulation at multiple levels, including the regulation of RAG1/2 activity, subnuclear reposition, spatial conformation of chromatin, and Vκ recombination, and …

Mar 11, 2011 · V(D)J recombination, which assembles antigen receptor genes during lymphocyte development, is initiated when the recombination activating gene 1 (RAG1) and RAG2 …