VCFS includes many common features: cleft palate, heart defects, and a characteristic facial appearance. Other common findings include minor learning problems and speech and feeding problems. Velocardiofacial syndrome is the most common syndrome associated with a …

Jun 29, 2017 · Velocardiofacial syndrome is the most common syndrome associated with a cleft palate. What is velocardiofacial syndrome? Velocardiofacial syndrome (VCFS) is a genetic condition that is sometimes hereditary. VCFS is characterized by a combination of medical problems that vary from child to child.

Nov 16, 2006 · Background: VCF is a 22q deletion syndrome which occurs in 1:4000 live births. It consists of dysmorphic facies, cleft palate, neurodevelopmental disorders and conotruncal cardiac defects. In addition to 22q11.2 deletion, other loci, e.g.10p4, have been implicated.

Velocardiofacial syndrome (VCFS) is a genetic disorder involving a cleft palate, structural heart problems and problems with the thymus and parathyroid glands.

Jul 10, 2020 · Velo-cardio facial syndrome has a number of common features including a cleft palate, heart abnormalities, and a characteristic looking face, and many others. What causes velo-cardio facial syndrome? While the exact cause is unknown, many children with VCFS have a missing portion of chromosome 22.

Velo: velopharyngeal dysfunction causing hypernasality. Usually secondary an occult submucous cleft or pharyngeal hypotonia. Can be due to an overt cleft palate or submucous cleft.

The major clinical manifestations of 22q11.2DS include congenital heart disease, particularly conotruncal malformations (ventricular septal defect, tetralogy of Fallot, interrupted aortic arch, and truncus arteriosus), palatal abnormalities (velopharyngeal incompetence, submucosal cleft palate, bifid uvula, and cleft palate), immune deficiency ...

Velo: A condition called “velopharyngeal dysfunction (insufficiency or incompetence)” can cause hypernasal speech. There may also be a cleft of the soft palate or a submucous (under the skin surface) cleft. Cardio: The individual with VCFS may have a history of a heart murmur or minor cardiac anomalies.

It is one of the most common genetic disorders in humans. The following list shows the anomalies that have been found in VCFS. No features are found in 100% of cases, but all occur with sufficient frequency to warrant assessment. If you have any questions, or if you would like to learn more about VCFS, you may reach.

DiGeorge and Velo-cardial-facial (VCF) Conditions • May have a 1/4000 newborn prevalence. • Very important cause of neonatal morbidity and of childhood learning delay. • Deletion not detectable by routine G-banded chromosome study • Variable clinical presentations, including near normal development. The two classical