UPCR < 0.5 defines complete response in guidelines and clinical trials when achieved after 1 or 2 years. Biomarkers of early response are needed to guide early treatment changes. We studied longitudinal urine proteomic profiles in LN to identify early predictors of proteinuric response.

Mar 24, 2020 · A first-morning-void UPCR also accurately reflects 24-hour proteinuria in LN. The gold standard for diagnosis and classification of LN is the percutaneous kidney biopsy.

For the LN group, we classified all participants as having normal range proteinuria (UPCR<0.15 g/g), mild proteinuria (0.15≤UPCR<0.5 g/g), moderate proteinuria (0.5≤UPCR<3.5 g/g), and massive proteinuria (UPCR≥3.5 g/g) based on UPCR results.

The ACR lupus classification criteria define LN by proteinuria >0.5 g/day or a urinary protein/creatinine ratio (UPCR) of >0.5 or urinary protein greater than 3+ by dipstick analysis or urinary cellular casts of more than five cells per high-power field (in …

May 3, 2023 · The Urine Protein/Creatinine Ratio (UPCR) is a test that measures the amount of protein in the urine in relation to the level of creatinine, a byproduct of muscle metabolism, present in the urine. The UPCR test is an important diagnostic tool …

A urine protein creatinine ratio test gives your healthcare provider important information about how your kidneys are working. This urine test is quick, painless and noninvasive. The results of a UPCR test can help your provider diagnose and monitor conditions that can damage your kidneys and affect your health.

Lupus nephritis (LN) is a frequent and serious manifestation of systemic lupus erythematous (SLE). Clinically overt LN occurs in about 40–60% of SLE patients, and this varies among racial and ethnic groups 1. LN is the result of glomerular accumulation of immune complexes (ICs).

Aug 24, 2022 · Lupus nephritis (LN) is one of the most frequent and severe organ manifestations of systemic lupus erythematosus (SLE) that is a chronic autoimmune disease. Despite improvement in patient and renal prognosis, the disease continued to be associated with a high rate of end stage kidney disease.

Dec 14, 2022 · UPCR < 0.5 defines complete response in guidelines and clinical trials when achieved after 1 or 2 years. Biomarkers of early response are needed to guide early treatment changes. We studied longitudinal urine proteomic profiles in LN to identify early predictors of proteinuric response.

Receiver operating characteristic curves were used to test the predictive values of urinary protein-to-creatinine ratio (UPCR), serum albumin and complement C3 at the first, second and third months as predictors for remission at the sixth month.