UBE2L3 is primarily known for its role in the cell cycle. Specifically, UBE2L3 manages cell cycle regulatory protein levels via the ubiquitin proteolytic pathway (UPP) during the G1/S transition and during the actual S phase .

Mar 30, 2025 · UBE2L3 (Ubiquitin Conjugating Enzyme E2 L3) is a Protein Coding gene. Diseases associated with UBE2L3 include Papilloma and Systemic Lupus Erythematosus. Among its related pathways are Selective autophagy and Class I …

Jul 20, 2023 · Here we report that deletion of Ube2l3 in mice reduces pro-IL-1β turnover in macrophages, leading to excessive mature IL-1β production, neutrophilic inflammation and disease following...

UBE2L3, also called UBcH7, is one of many E2 ubiquitin conjugating enzymes that participate in the ubiquitination of many substrate proteins and regulate many signaling pathways, such as the NF-κB, GSK3β/p65, and DSB repair pathways.

UBE2L3 regulates TLR7-induced B cell autoreactivity in Systemic Lupus Erythematosus. UBE2L3 promotes squamous cell carcinoma progression in the oral cavity and hypopharynx via activating the NF-kappaB signaling by increasing IkappaBalpha degradation.

Treatment with a caspase 1 inhibitor reversed the decrease in the level of UBE2L3. In addition, UBE2L3 overexpression reduced TRIM21, decreased signal transducer and activator of transcription 3 pathway activity, and reduced the level of the IL-1β precursor (pro‒IL-1β).

Sep 24, 2013 · As increased UBE2L3 expression enhances NF-κB activation, and increased levels of NF-κB activity are linked to inflammatory and autoimmune diseases, the data suggest a mechanism by which UBE2L3...

Jul 1, 2020 · In vivo, knockout of UBE2L3 in HCC cells inhibited tumour growth in orthotopic liver injection nude mouse models. Moreover, inhibition of p65 or GSK3β significantly restored the effects induced by UBE2L3 knockout in HCC.

Feb 2, 2015 · UBE2L3 is an E2 ubiquitin-conjugating enzyme, specially adapted to function with HECT and RING-in-between-RING (RBR) E3 ligases, including HOIL-1 and HOIP, components of the linear ubiquitin chain assembly complex (LUBAC).

Jan 29, 2025 · UBE2L3, as an E2 ubiquitin ligase involved in the ubiquitination of various substrate proteins. Studies have demonstrated that UBE2L3 is aberrantly expressed in cancer cell lines and tumor tissues, indicating its involvement in various cancer-related signaling pathways.