UTP—glucose-1-phosphate uridylyltransferase is an enzyme found in all three domains (bacteria, eukarya, and archaea) as it is a key player in glycogenesis and cell wall synthesis.

The primary synthesis of UDP-sugars is catalyzed by specific pyrophosphorylases, which use UTP and a sugar-1-P (which may be N -acetylated) as substrates to form inorganic pyrophosphate (PP i) and the corresponding UDP-sugar.

Oct 2, 2018 · Given the reversible nature of the Glc1P/UDP-Glc reaction, our results indicate that UGP-Glc pyrophosphorylase is the major target when excess PPi exerts inhibitory effects in vivo.

So, glucose 1-phosphate reacts with uridine triphosphate (UTP) to form uridine diphosphate glucose (UDPG) via UDPG pyrophosphorylase catalysis. This reaction produces pyrophosphate (PPi) which is hydrolyzed in a thermodynamically highly favorable reaction catalyzed by pyrophosphatase.

UDP- N -acetylglucosamine pyrophosphorylase (UAP1) catalyses the last step in eukaryotic biosynthesis of uridine diphosphate- N -acetylglucosamine (UDP-GlcNAc), converting UTP and GlcNAc-1P to the sugar nucleotide.

UDP-sugar pyrophosphorylase (USPase; EC 2.7.7.64) catalyzes a reversible transfer of the uridyl group from UTP to sugar-1-phosphate, producing UDP-sugar and pyrophosphate (PPi).

Glucose-1 phosphate reacts with UTP to form UDP phosphate and PPi. Although the reaction is readily reversible, the pyrophosphate that is produced is rapidly hydrolyzed, and THAT essentially irreversible hydrolysis drives the reaction making it delta G equals -19.2 KJ/ mol

Jun 20, 2022 · UDP-glucose pyrophosphorylase (UGPase) carries a freely reversible reaction, using glucose-1-P and UTP to produce UDP-glucose (UDPG) and pyrophosphate (PP i), with UDPG being essential for glycosylation reactions in all organisms including, e.g., synthesis of sucrose, cellulose and glycoproteins.

UDP-glucose pyrophosphorylase (UGPase) is an important enzyme in the metabolism of UDP-glucose, a precursor for the synthesis of cell wall carbohydrate components, such as cellulose and callose. You might find these chapters and articles relevant to this topic.

The hydrolysis of pyrophosphate (PPi) to 2 orthophosphates (Pi) by pyrophosphatase drives the reaction to completion. The overall net equation becomes: Glucose 1-phosphate + UTP <---> UDP-glucose + 2 Pi which is very exergonic.