Dec 15, 2021 · This editorial focuses on common issues that surround the diagnosis of usual interstitial pneumonia (UIP), a clinically significant pathologic diagnosis. Most of these issues stem from conflation of the pathologically defined entity UIP with the clinically defined entity IPF.

Usual interstitial pneumonia (UIP) is a form of lung disease characterized by progressive scarring of both lungs. [1] The scarring (pulmonary fibrosis) involves the pulmonary interstitium (the supporting framework of the lung). UIP is thus classified as a form of interstitial lung disease.

Feb 7, 2022 · Usual interstitial pneumonia, abbreviated UIP, is a relatively common pattern in diffuse lung diseases. Overall, it is an uncommon pathology. Idiopathic pulmonary fibrosis (abbreviated IPF) redirects here.

Pathology of usual interstitial pneumonia (UIP): (A) Areas of fibrosis are mainly located in the peripheral zones of secondary lobules. (B) Patchy dense fibrosis affects the peripheral area inside the lobule and the perivenular area (arrowhead).

Oct 3, 2022 · Usual interstitial pneumonia (UIP) is the most common pattern of disease and the scarring caused by UIP can be seen on imaging such as a CT scan and under the microscope. In fact, the diagnosis of UIP can often be made with imaging alone.

May 1, 2017 · Patient with digital tip ulceration for 6 months, high titer Scl-70 histological UIP pattern with little cellular inflammation. Patient with 2 year history of pulmonary hypertension who died of acute exacerbation.

Aug 31, 2021 · Over the past 50 years, the pathologic diagnostic term UIP has evolved from the “usual” type of interstitial lung disease that included both fibrotic and acute forms to a rigidly defined...

Oct 14, 2024 · Pathology. The histological diagnosis of UIP is based on temporal and spatial heterogeneity, the identification of fibrotic lesions at different stages (fibroblastic infiltrates, mature fibrosis, and honeycombing) within the same biopsy specimen and architectural distortion.

Jan 2, 2020 · Usual interstitial pneumonia (UIP) refers to a morphologic entity defined by a combination of (1) patchy interstitial fibrosis with alternating areas of normal lung, (2) temporal...

This manuscript reviews the progressive history of the histologic diagnosis of UIP and summarizes the current state of histologic UIP and its relationship to the clinical syndrome idiopathic pulmonary fibrosis (IPF).