Mar 16, 2018 · In addition cell viability and apoptosis as well as autophagy-associated proteins were evaluated. Melatonin was able to protect heart function from LPS, which weakened in the …

UCP2 knocked out mice and cardiomyocytes were used to study the effect of melatonin in response to LPS. Indicators of myocardial and mitochondria injury including mitochondrial …

Mar 16, 2018 · Melatonin was able to protect heart function from LPS, which weakened in the UCP2-knockout mice. Consistently, genipin, a pharmacologic inhibitor of UCP2, augmented …

To explore the mechanism of mitochondrial uncoupling protein 2 (UCP2) mediating the protective of melatonin when septic cardiomyopathy. UCP2 knocked out mice and cardiomyocytes were …

Aug 16, 2016 · Objective: To observe the expression of uncoupling protein (UCP2) and its effect on modulation of mitochondrial function and apoptosis of cardiomyocytes exposed to high …

Aug 8, 2019 · Accordingly, a human cardiomyocyte cell line (AC16) that was treated with tesaglitazar (50 μM and 100 μM) for 24 hours showed decreased mitochondrial abundance …

Aug 21, 2011 · The mitochondrial membrane protein Ucp2, which acts to lower the mitochondrial membrane potential7,8,9, was upregulated in phagocytes engulfing apoptotic cells.

Jun 1, 2022 · Uncoupling protein 2 (UCP2) is a sub-type of the uncoupling protein family and is primarily expressed in the myocardial tissue. Our results thus suggest that the UCP2 level …

Mar 30, 2023 · In general, UCP2 may reduce oxidative stress by mild uncoupling and both UCP2 and UCP3 affect substrate utilization in cardiac tissue, thereby modifying post-ischemic …

Aug 1, 2015 · Cytotoxic and mitochondrial bioenergetic effects of MeHgCl was examined in two cardiomyocyte cell lines; H9C2 and AC16. H9C2 and AC16 cells show dose dependant …