Here we show that depletion of Cyclin A or inhibition of Cdk2 during late S/early G2 phase maintains the G2 phase arrest by reducing Cdh1 transcript and protein levels, thereby …

Jun 12, 2017 · Here we provide evidence demonstrating that APC Cdh1 plays a critical role in choosing the repair pathways in S/G2 cells. Our results suggest that the default for all DSBs is …

We found that depletion of Cdh1 in HeLa, U2OS, and primary human fibroblasts led to an up-regulation of Claspin, and subsequent increase in activation of Chk1 activity, as determined by …

Here, we show that Cdh1 depletion causes increased levels of genomic instability and enhanced sensitivity to DNA-damaging agents. Using an integrated proteomics and bioinformatics …

May 20, 2011 · We show that the deubiquitinase USP37 binds CDH1 and removes degradative polyubiquitin from cyclin A. USP37 was induced by E2F transcription factors in G1, peaked at …

Oct 12, 2015 · Using biochemistry and live cell imaging of single cells we found that Cdh1 knockdown (kd) leads to strong nuclear stabilization of the substrates cyclin A and B and …

Feb 2, 2023 · In this paper, we show how cyclin E can promote WGD in p53-proficient cells and how p53 can contribute to the generation of WGD. To study the consequences of elevated …

Jul 25, 2008 · Here, we show that, in response to genotoxic stress in G2, the phosphatase Cdc14B translocates from the nucleolus to the nucleoplasm and induces the activation of the …

Oct 14, 2013 · The sequestration of CDH1 by MAD2L2 acts to prevent premature activation of the APC/C by preventing binding of CDH1 to hypophosphorylated forms of the complex, thus …

Because Cdh1 is a crucial regulator of cell-cycle progression, its function is tightly controlled in vivo. Cdh1 associates with the APC core complex in the late M phase to activate APC/Cdh1, …