U1 spliceosomal RNA is the small nuclear RNA (snRNA) component of U1 snRNP (small nuclear ribonucleoprotein), an RNA-protein complex that combines with other snRNPs, unmodified pre-mRNA, and various other proteins to assemble a spliceosome, a large RNA-protein molecular complex upon which splicing of pre-mRNA occurs.

Dec 1, 2021 · U1 small nuclear RNA (U1 snRNA), as one of the most abundant ncRNAs in human cells, plays an important role in splicing of pre-mRNAs. Compared to previous studies which have focused on the primary function of U1 snRNA and the neurodegenerative ...

The U1 small nuclear RNA (snRNA) is an abundant 164 nt long noncoding RNA. It is a critical component of the spliceosome, a dynamic macromolecular complex that catalyzes pre-mRNA splicing by removing noncoding introns and ligating coding exons ( Will and Luhrmann 2011 ).

Sep 23, 2024 · Here we describe an RNA-centric approach that identified more than 200 proteins associated with the Arabidopsis U1 snRNP and revealed a tight link to mRNA cleavage and polyadenylation factors.

Several reviews have extensively described the concept of U1 telescripting and subsequently highlighted its potential impacts in mRNA metabolism. Here, we review what is currently known regarding the underlying mechanisms of this important phenomenon and discuss open questions and future challenges.

Mar 11, 2020 · Using this method, we discovered an RNA motif that recognizes the U1 small nuclear ribonucleoprotein (snRNP) and is essential for the localization of reporter RNAs to chromatin.

Feb 25, 2022 · An exon-specific U1 small nuclear RNA (snRNA) strategy to correct splicing defects.

Oct 9, 2019 · Here we report a highly recurrent A>C somatic mutation at the third base of U1 snRNA in several types of tumour. The primary function of U1 snRNA is to recognize the 5′ splice site via...

Mar 26, 2024 · U1 snRNA, particularly RNVU1-18, is inducible in the host infected with RNA viruses, including IAV, SeV, VSV, EMCV, and RSV. Overexpression of U1 snRNA protects host cells against RNA viruses, while knockdown of U1 snRNA significantly leads to more viral burden in vitro and in vivo.

Sep 26, 2014 · Excellent reviews exist detailing the role of U1 snRNA in pre-mRNA splicing events. This review highlights what is currently known regarding the additional roles, snRNP composition, expression profiles, and the genomic organization of this ncRNA.