TYRO3 - Wikipedia
Tyrosine-protein kinase receptor TYRO3 is an enzyme that in humans is encoded by the TYRO3 gene. [5] [6]
The Emerging Role of TYRO3 as a Therapeutic Target in Cancer
Recent studies revealed roles for TYRO3 in cancer and suggest TYRO3 as a therapeutic target in this context. TYRO3 is overexpressed in many types of cancer and functions to promote tumor …
TYRO3 Gene - GeneCards | TYRO3 Protein | TYRO3 Antibody
Mar 30, 2025 · TYRO3 (TYRO3 Protein Tyrosine Kinase) is a Protein Coding gene. Diseases associated with TYRO3 include Lymphocytic Choriomeningitis and Retinitis Pigmentosa 38. …
TYRO3 induces anti-PD-1/PD-L1 therapy resistance by limiting …
Apr 15, 2021 · Inhibition of TYRO3 promoted tumor ferroptosis and sensitized resistant tumors to anti-PD-1 therapy. Collectively, our findings suggest that TYRO3 could serve as a predictive …
Tyro3, Axl, Mertk receptor-mediated efferocytosis and immune …
Three structurally related tyrosine receptor cell surface kinases, Tyro3, Axl, and Mertk (TAM) have been recognized to modulate immune function, tissue homeostasis, cardiovasculature, and …
TYRO3: A potential therapeutic target in cancer - PMC
Targeting TYRO3 could break the kinase signaling, stimulate antitumor immunity, reduce tumor cell survival, and regain drug sensitivity. To date, there is no specific TYRO3-targeted drug, …
Discovery of Novel TYRO3/MERTK Dual Inhibitors - PubMed
Apr 11, 2025 · The TAM (TYRO3, AXL, MERTK) family of receptor tyrosine kinases has roles in oncogenesis and innate immunity, but the relative importance of the family members can differ …
TYRO3 TYRO3 protein tyrosine kinase [ Homo sapiens (human) ]
Oct 10, 2024 · Title: TYRO3 promotes tumorigenesis and drug resistance in colorectal cancer by enhancing the epithelial-mesenchymal transition process. Targeting BRD3 eradicates nuclear …
Immunobiology of the TAM receptors - Nature Reviews Immunology
The TAM receptor protein tyrosine kinases — TYRO3, AXL and MER — have important roles in the immune, nervous, reproductive and vascular systems. Two closely related proteins —...
TYRO3 TYRO3 protein tyrosine kinase [ (human)] - National …
TYRO3 is upregulated in colorectal cancer cells and is a direct target gene of miR-7. Data suggest that TYRO3-mediated phosphorylation of ACTN4 is involved in invasiveness of melanoma …