Type III Collagen is a homotrimer, or a protein composed of three identical peptide chains (monomers), each called an alpha 1 chain of type III collagen. Formally, the monomers are called collagen type III, alpha-1 chain and in humans are encoded by the COL3A1 gene.

Type III collagen, first identified and described in 1971 (Miller et al., 1971), is an important structural protein, classified as one of the major fibrillar collagens (Prockop and Kivirikko, 1995). It constitutes about 5–20% of the entire collagen content in the human body (Miller, 1988).

Apr 22, 2020 · Type III collagen works alongside type I in skin, ligaments, blood vessels, and joints too. Type III collagen is found in grass-fed bovine collagen but not marine. This type of collagen "promotes skin health and elasticity—or what gives you that bounce-back in the skin," says Cook-Bolden.*

Collagen I is a stiff fibrillar protein that gives tensile strength, whereas Col III produces an elastic network that stores kinetic energy as an elastic rebound. These two collagen proteins have distinct physical properties in nature.

May 23, 2022 · All collagen fibrils have at least one triple helix structure. The main five types of collagen and what they do are: Type I. This type makes up 90% of your body’s collagen. Type I is densely packed and used to provide structure to your skin, bones, tendons and ligaments. Type II. This type is found in elastic cartilage, which provides joint ...

Collagen Type 3, also known as type III collagen, is a protein that consists of three identical chains of α1(III). It is found in various tissues including the skin, arteries, and uterine tissue, and is often present alongside Type I collagen.

Jul 30, 2019 · Collagen alpha-1(III) chain, also known as the alpha 1 chain of type III collagen, is a protein that in humans is encoded by the COL3A1 gene. Three alpha 1 chains are required to form the type III collagen molecule which has a long triple-helical domain.

Jan 1, 2024 · Type III collagen is a fibrillar collagen of homotrimers containing α1(III) chains supercoiled around one another in a right-handed triple helix. Type III collagen is secreted by fibroblasts and other mesenchymal cell types, making it a major player in various inflammation-associated pathologies, such as lung injury, arthropathies, liver ...

Type III collagen is a fibrillar forming collagen comprising three α1 (III) chains and is expressed in early embryos and throughout embryogenesis. In the adult, type III collagen is a major component of the extracellular matrix in a variety of internal organs and skin.

We generated a transgenic mouse line expressing mutant type III collagen, containing a typical helical glycine substitution (p. (Gly182Ser)). This Col3a1 Tg-G182S mouse line displays a phenotype recapitulating characteristics of human vEDS patients with signs of dermal and vascular fragility.