Feb 5, 2015 · Replacement therapy with plasma-derived von Willebrand factor-factor VIII concentrates represents the safe mainstay of treatment of all patients, particularly those not responding to desmopressin or requiring a sustained hemostatic correction because of major surgery or bleeding.

May 15, 2024 · Type 2 is further broken down into four subtypes―2A, 2B, 2M, and 2N―depending on the specific problem with the person's VWF. Because the treatment is different for each type, it's important that a person know which subtype he or she has.

Type 2 VWD is the next most common type. About 15% of people with VWD have Type 2. They usually have more severe bleeding problems than people with Type 1. In Type 2 VWD, there is enough von Willebrand factor, but it does not work as it should. VWF has different ways that make it not work correctly.

Von Willebrand disease (VWD) is characterized by mucocutaneous bleeding and excessive bleeding with trauma and procedures. Individuals with more severe forms of VWD are also at-risk for musculoskeletal bleeding.

VWD Type 2A results from a loss-of-function mutation in von Willebrand factor (VWF), leading to reduced binding of VWF with Platelet GP1b receptors. This disorder follows an autosomal dominant inheritance pattern with only occasional cases following autosomal recessive pattern.

Mar 22, 2018 · Type 2B von Willebrand disease (VWD) is an inherited bleeding disorder caused by changes in von Willebrand factor (VWF) that enhance binding of VWF to GPIb on platelets.

Most people have Type 1 or Type 2 von Willebrand disease and may only need treatment if they’re injured or need surgery. People with Type 3 von Willebrand disease may need ongoing medical treatment to manage bleeding.

There are four main subtypes of type 2 VWD. These are 2A, 2B, 2M and 2N. Type 2A – The VWF multimers are not the right size. Type 2B – The VWF multimers are not the right size and the VWF becomes too active. It attaches to the platelets in the blood when it is not supposed to.

Dec 1, 2009 · There are three major subtypes of von Willebrand disease, classified as partial quantitative deficiency (low levels) of von Willebrand factor (type 1), qualitative deficiency (type 2), or...

A form of von Willebrand disease (VWD) characterized by a bleeding disorder associated with a qualitative deficiency and functional anomalies of the Willebrand factor (VWF). Depending on the type of functional abnormalities, this form is classified as type 2A, 2B, 2M or 2N.