Tropomyosin receptor kinase A (TrkA), [5] also known as high affinity nerve growth factor receptor, neurotrophic tyrosine kinase receptor type 1, or TRK1-transforming tyrosine kinase protein is a protein that in humans is encoded by the NTRK1 gene.

TRKA receptors are involved in pain sensation; loss-of-function mutations in TRKA are observed in class IV hereditary sensory and autonomic neuronal disorders (such as congenital insensitivity to pain with anhidrosis), which result in impaired ability to …

The TrkA receptor is a neurotrophin-binding tyrosine kinase receptor that plays a crucial role in signal transduction and cellular responses to nerve growth factor (NGF) and other neurotrophins.

This manuscript describes the development of an analgesic that suppresses NGF/TrkA signaling, which is anticipated to be 1 of the new methods to treat intractable pain. Keywords: NGF; TrkA; anti-NGF antibody; local anesthetic; nerve growth factor; pain; protein kinase; review; tanezumab; tropomyosin receptor kinase.

Feb 1, 2010 · TrkA is a receptor tyrosine kinase able to activate multiple downstream second-messenger signaling cascades and promote nociceptor excitability via sensitization of several ion channels, including TRPV1, ASIC3, P2X3, and NaV.

TrkA is a receptor tyrosine kinase (RTK) consisting of five extracellular domains (ECDs) (D1–D5) which resemble a “crab-claw” shape, an α-helical transmembrane (TM) domain, and an intracellular segment which includes a kinase domain that is structurally highly conserved between all RTKs (Fig. 1).

Schematic view of TRK receptor tyrosine kinases and major signal transduction pathways involved in cell differentiation, proliferation, and survival. TRKA is activated by nerve growth factor (NGF), TRKB is activated by brain-derived neurotrophic factor (BDNF), and TRKC is activated by neurotrophin-3 (NT3).

Dec 12, 1994 · The present investigation used an antibody directed against the extracellular domain of the signal transducing nerve growth factor receptor, trkA, to reveal immunoreactive perikarya or fibers within the olfactory bulb and tubercle, cingulate cortex, nucleus accumbens, striatum, endopiriform nucleus, septal/diagonal band complex, nucleus basalis,...

Sep 17, 2020 · The tyrosine kinase receptor A (NTRK1/TrkA) is increasingly regarded as a therapeutic target in oncology. In breast cancer, TrkA contributes to metastasis but the clinicopathological significance remains unclear.

Jul 7, 2018 · Tropomyosin receptor kinase A (TRKA) is a membrane-bound, glycosylated receptor tyrosine kinase and the high-affinity binding partner of nerve growth factor (NGF). This protein is a member of the neurotrophic tyrosine kinase receptor (NTKR) family and is …