E3 ubiquitin-protein ligase TRIM33, also known as (ectodermin homolog and tripartite motif-containing 33) is a protein encoded in the human by the gene TRIM33, a member of the tripartite motif family.

Mar 30, 2025 · TRIM33 (Tripartite Motif Containing 33) is a Protein Coding gene. Diseases associated with TRIM33 include Differentiated Thyroid Carcinoma and Developmental Dysplasia Of The Hip 1. Among its related pathways are Gene expression (Transcription) and Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer.

TRIM33, also called TIF1γ, is the third member found in the TIF1 family. Like TRIM28, TRIM33 is also a multifunctional protein with many biological functions. It was initially discovered as a transcription co-repressor and exhibited a strong silencing activity when tethered to a promoter (Venturini et al., 1999).

May 31, 2024 · TRIM33 promoted the transcription of Irf8 to facilitate the differentiation of cDC1s by maintaining adequate CDK9 and Ser2 phosphorylated RNA polymerase II (S2 Pol II) levels at Irf8 gene...

Apr 12, 2024 · Trim33 -deficient mice displayed a near-complete loss of multiple DC subsets with minimal impact on monocytes or granulocytes. During DC differentiation, Trim33 repressed expression of type I interferon and genes associated with other myeloid lineages.

Feb 2, 2015 · Here we demonstrate that the tripartite motif-containing protein 33 (TRIM33), acting as an E3 ubiquitin ligase, reduces the abundance of nuclear β-catenin protein. TRIM33-mediated β-catenin is...

TRIM33 binds to DHX33 directly and induces K63-linked ubiquitination. Since we found that TRIM33 is in a DHX33-interacting protein complex and TRIM33 is an E3 ubiquitin ligase, we next investigated whether DHX33 is the ubiquitination target of TRIM33.

Feb 9, 2025 · TRIM33 prevents pulmonary fibrosis by impairing TGF-beta1 signalling. TRIM33 Overexpression Inhibits the Progression of Clear Cell Renal Cell Carcinoma In Vivo and In Vitro. Trim24 and Trim33 Play a Role in Epigenetic Silencing of Retroviruses in Embryonic Stem Cells.

TRIM33 can function either as a tumor suppressor or tumor promoter in different cancers. Our data showed that TRIM33 was highly expressed in stomach cancer, and in human gastric cancer tissues, low expression of TRIM33 was associated with …

Aug 23, 2023 · We propose that the Trim33-E2f4-Recql axis controls progression of DNA replication forks along transcriptionally active chromatin to maintain genome integrity.