Jan 16, 2023 · Two classical anti-inflammatory cell types, regulatory T cells (Tregs) and M2 macrophages, are theoretically capable of resisting uncontrolled inflammation. Recent studies have indicated possible...

Jul 17, 2023 · Mechanisms of Treg-mediated lung parenchymal tissue protection and repair. Tregs exert distinct functions to provide tissue protection and promote repair of the epithelial, endothelial, and mesenchymal compartments following infection-induced lung injury.

Treg are required for maintenance of self-tolerance, preventing excessive inflammation and autoimmune diseases. The most reliable cell-specific marker of Treg is Forkhead box P3 (FOXP3), which is essential for the maturation and function of Treg.

Mar 6, 2023 · Here, we describe local interactions between Treg cells and an Areg-responsive population of Col14a1+EGFR+ lung mesenchymal cells that mediate type II alveolar epithelial (AT2) cell-mediated regeneration following influenza virus infection.

Tregs constitute a small subpopulation of CD4+ T cells that maintain homeostasis under multiple immune scenarios. These cells develop either naturally (nTregs, developed in the thymus) or after peripheral induction (iTregs, arising in peripheral circulation from conventional T cells).

Oct 31, 2023 · Regulatory T (Treg) cells have been shown to be important in maintaining immune homeostasis and preventing inflammatory damage, including lung diseases.

Feb 28, 2023 · Our results demonstrate that TNFR2 is critical for Treg cell-mediated regulation of pulmonary γδT17-neutrophil axis, with impaired TNFR2 + Treg cell responses increasing susceptibility to disease.

Regulatory T-cell (Treg) control of alveolar repair following acute lung injury (ALI). In the context of LPS-induced ALI in a preclinical animal model, recovery from inflammation and lung repair requires Tregs.

May 2, 2024 · In 2023, several key papers have highlighted the capacity of lung Tregs to mediate tissue repair and to modulate the lung environment in response to self-antigen versus foreign antigen (Figure 1). Here, we discuss four papers from 2023 on the molecular mechanisms underlying Tregs function and the physiological significance of Tregs in the lung.

2 days ago · Background Chronic obstructive pulmonary disease (COPD) is a common disease with respiratory symptoms and limited airflow. Exosomes derived from Tregs (Treg-exo) could regulate immune function and prevent autoimmune disease. This study assessed Treg-exo effects on COPD. Methods In vivo, rats were divided into three groups including control, COPD and exosomes groups. COPD models were ...