TRAMP-C2 is an epithelial cell line that was isolated in 1996 from the prostate of an adult, male transgenic mouse with adenocarcinoma. This cell line was deposited by N Greenberg and can be used in drug development.

The transgenic adenocarcinoma of the mouse prostate (TRAMP) model closely mirrors the pathogenesis of human prostate cancer. Male TRAMP mice uniformly and spontaneously develop autochthonous (orthotopic) prostate tumors following the onset of puberty.

Aug 15, 1997 · TRAMP is a transgenic line of C57BL/6 mice harboring a construct comprised of the minimal -426/+28 rat probasin promoter driving prostate-specific epithelial expression of the SV40 large T antigen.

The TRAMP-C1 (C1) and TRAMP-C2 (C2) cell lines were derived from a prostate tumor that arose in a mouse from the transgenic adenocarcinoma mouse prostate (TRAMP) model.

Characterization of prostatic epithelial cell lines derived from transgenic adenocarcinoma of the mouse prostate (TRAMP) model.

Nov 6, 2022 · We analysed the current literature regarding the role of natural and synthetic compounds in modulating NRF2 pathway in TRAMP mice, an in vivo model of prostate cancer, to give an overview on prostate carcinogenesis and its possible prevention.

Dec 1, 2001 · TRAMP-C1 is a hormone-independent PCa cell line derived from a TRAMP tumor and is widely used to establish orthotopic and subcutaneous murine model of prostate cancer.

Nov 1, 2021 · In another study, Yu and colleagues examined the effect of IL-15 as a stimulator of CD8 T cell, NK, and NKT cell in combination therapy with anti-PDL1 and anti-CTLA-4 antibodies in (TRAMP) -C2 model of prostate cancer.

Jul 24, 2013 · It was found that TRAMP-derived PCSCs represent a novel and valuable preclinical model for elucidating the pathogenetic mechanisms leading to prostate adenocarcinoma and for the identification of molecular mediators to be pursued as therapeutic targets. Keywords: Cancer, Cancer stem cells, Gene expression, Neoplastic stem cell biology.

Mar 6, 2018 · Researchers have developed a mouse model that might be useful in developing prostate cancer treatments. Lardizabal and co-workers generated the TRAMP-derived orthotopic prostate syngeneic (TOPS)...