It is a DNA topoisomerase, an enzyme that catalyzes the transient breaking and rejoining of a single strand of DNA. This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription.

Founded in 1979 by William “Bill” Ryan, TOP 1 Oil Products Company, U.S.A. produces and distributes a range of synthetic and conventional lubricants, greases, automotive fluids, and car-care products.

Mar 30, 2025 · TOP1 (DNA Topoisomerase I) is a Protein Coding gene. Diseases associated with TOP1 include Hematologic Cancer and Spinocerebellar Ataxia, Autosomal Recessive, With Axonal Neuropathy 1. Among its related pathways are Transport of the SLBP independent Mature mRNA and Metabolism of proteins.

In this article, we discuss the characteristics of topoisomerase (DNA) I (TOP1) and its inhibitors, as well as the underlying DNA repair pathways and the use of TOP1 inhibitors in cancer therapy.

Mammalian topoisomerase 1 (TOP1) is an essential enzyme for normal development. TOP1 relaxes supercoiled DNA to remove helical constraints that can otherwise hinder DNA replication and transcription and thus block cell growth.

Jun 5, 2022 · Topoisomerase IB (Top1), a subcategory of DNA topoisomerase enzymes is expressed much higher in several tumor cells. Therefore, modulating the activity of Top1 in tumor cells to prevent DNA replication and subsequent cell division made it an important drug target for anticancer therapy.

We introduce new therapeutic strategies based on novel TOP1 inhibitor chemical scaffolds including the indenoisoquinolines LMP400 (indotecan), LMP776 (indimitecan) and LMP744, and on tumor-targeted delivery TOP1 inhibitors (TTTis) …

Results identified TOP1 gene copy gain, a loss of chromosome 20, and new yet unreported TOP1 mutations (R364K and G717R) in close proximity to the SN-38 binding site conferring colon cancer cells resistance to the drug.

Feb 9, 2025 · Gene target information for TOP1 - DNA topoisomerase I (human). Find diseases associated with this biological target and compounds tested against it in bioassay experiments.

May 24, 2024 · During catalytic activity, topoisomerase I forms a transient intermediate, topoisomerase I–DNA cleavage complex (Top1cc) to allow strand rotation and duplex relaxation, which can lead to elevated levels of DNA-RNA hybrids and micronuclei.