Toll interacting protein, also known as TOLLIP, is an inhibitory adaptor protein that in humans is encoded by the TOLLIP gene. [5][6][7] It is an inhibitory adaptor protein within Toll-like receptors (TLR). [8] .

TOLLIP (Toll-interacting protein) is an intracellular adaptor protein with diverse actions throughout the body. In a context- and cell type–specific manner, TOLLIP can function as an inhibitor of inflammation and endoplasmic-reticulum stress, an ...

Feb 1, 2012 · The Toll-interacting protein (Tollip) is a critical regulator of Toll-like receptor (TLR)-mediated innate immune responses. Tollip modulates TLR signaling and membrane trafficking processes through its interaction with both proteins and phosphoinositides. Here, I discuss the multitasking role of Tollip associated with its modular architecture.

Tollip is a ubiquitously expressed protein, originally described as a modulator of the IL-1R/TLR-NF-κB signaling pathways. Although this property has been well characterized in peripheral cells, and despite some evidence of its expression in the ...

Mar 25, 2024 · Toll-interacting protein (TOLLIP) prevents inflammation and lipid accumulation in alveolar macrophages to limit integrated stress response activation, macrophage necrosis and promote control...

Toll-interacting protein (Tollip) is a key negative regulator of innate immunity by preventing excessive proinflammatory responses. Tollip genetic variation has been associated with airflow limitation in asthma subjects and Tollip expression. ...

Mar 30, 2025 · TOLLIP (Toll Interacting Protein) is a Protein Coding gene. Diseases associated with TOLLIP include Lymphoproliferative Syndrome, X-Linked, 1 and Idiopathic Interstitial Pneumonia. Among its related pathways are Innate Immune System …

TOLLIP exists in a delicate homeostatic balance, with both positive and negative effects on the trajectory of pulmonary diseases. This translational review summarizes the genetic and molecular associations that link TOLLIP to the development and progression of noninfectious and infectious pulmonary diseases.

Toll-interacting protein (TOLLIP) is a ubiquitous intracellular adaptor protein involved in multiple intracellular signaling pathways. It plays a key role in mediating inflammatory intracellular responses, promoting autophagy, and enabling vacuole transport within the cell.

Nov 11, 2012 · Results: Tollip interacts with Smad7 and TGF-β receptors and negatively regulates cellular signaling and function of TGF-β. Conclusion: Tollip modulates intracellular trafficking and degradation of TGF-β receptors. Significance: Tollip is a novel modulator of TGF-β …