Activated CDC42 kinase 1, also known as ACK1, is an enzyme that in humans is encoded by the TNK2 gene. [5][6][7][8][9] TNK2 gene encodes a non-receptor tyrosine kinase, ACK1, that binds to multiple receptor tyrosine kinases e.g. EGFR, MERTK, AXL, HER2 and insulin receptor (IR).

Mar 30, 2025 · Complete information for TNK2 gene (Protein Coding), Tyrosine Kinase Non Receptor 2, including: function, proteins, disorders, pathways, orthologs, and expression.

Feb 8, 2025 · TNK2 (and TNR) harbored rare, genetic variants in individuals with familial Parkinson's Disease. Our results indicate that ACK1 is an independent prognostic marker and promotes hepatocellular carcinoma progression

Oct 27, 2014 · The emergence of a non-receptor tyrosine kinase (non-RTK), ACK1 (also known as activated Cdc42-associated kinase 1 or TNK2) as an oncogenic kinase, has uncovered novel mechanisms by which...

By correlating our phosphoproteomic data with oncogenic phenotypes, we identified the non-receptor tyrosine kinase, TNK2, as a protein that was hyperphosphorylated in a majority of aggressive TNBC cell lines, suggesting that TNK2 is a regulator of TNBC growth and proliferation.

Jan 1, 2025 · Activated CDC42-associated kinase 1 (ACK1), encoded by the TNK2 gene, is a cytoplasmic non-receptor tyrosine kinase whose aberrant activation correlates positively with cancer severity. Recent research has revealed the functional relevance of this oncokinase – it is an epigenetic regulator that drives cancer progression in multiple malignancies.

Gene target information for TNK2 - tyrosine kinase non receptor 2 (human). Find diseases associated with this biological target and compounds tested against it in bioassay experiments.

ACK1 is an atypical class VIII oncogenic non-receptor tyrosine kinase encoded TNK2 gene by the reg-on human chromosome 3q29 1]. [It is a cytoplasmic protein of 1038 amino acids that phos-expressed in bone marrow and lymphoid tissues, as well as in brain, muscle, gastrointestinal H3 at tract, liver, and skin https://www.proteinatlas.org).

Here we show that a non-receptor tyrosine kinase, TNK2/ACK1 (tyrosine kinase non receptor 2), phosphorylated ATP5F1A (ATP synthase F1 subunit alpha) at Tyr243 and Tyr246 (Tyr200 and 203 in the mature protein, respectively) that not only increased the stability of complex V, but also increased mitochondrial energy output in cancer cells.

Nov 13, 2013 · HGNC Approved Gene Symbol: TNK2. Cytogenetic location: 3q29 Genomic coordinates (GRCh38) : 3:195,863,364-195,908,551 (from NCBI) The TNK2 gene encodes a …