Mar 30, 2025 · TNFRSF14 (TNF Receptor Superfamily Member 14) is a Protein Coding gene. Diseases associated with TNFRSF14 include Herpes Simplex and Leukemia, Chronic Lymphocytic. Among its related pathways are Akt Signaling and TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions.

Herpesvirus entry mediator (HVEM), also known as tumor necrosis factor receptor superfamily member 14 (TNFRSF14), is a human cell surface receptor of the TNF-receptor superfamily [5] [6] [7] [8] encoded by the TNFRSF14 gene.

Mar 26, 2025 · Title: Increased expression of TNFRSF14 and LIGHT in biliary epithelial cells of patients with primary sclerosing cholangitis. MIF promotes Th17 cell differentiation in Hashimoto's thyroiditis by binding HVEM and activating NF-kappaB signaling pathway.

TNFRSF14 gene aberrations, common in FL, increase the ability of lymphoma cells to stimulate allogeneic T-cell responses. TNFRSF14 lesions were associated with increased acute GVHD supporting stratified transplantation approaches in the allogeneic setting.

Tumor necrosis factor (TNF) superfamily ligands show diverse biological functions, such as the induction of apoptotic cell death or cell survival and proliferation, making them excellent therapeutic targets for cancer and autoimmunity. We review the latest literature on TNF receptor superfamily signaling with a focus on structure-function.

The tumor necrosis factor (TNF) receptor superfamily member herpesvirus entry mediator (HVEM) (TNFRSF14) regulates T-cell immune responses by activating both inflammatory and inhibitory signaling pathways.

Tumor necrosis factor receptor superfamily member 14 (TNFRSF14) is dysregulated in certain types of cancer; however, limited data are available on the expression and function of TNFRSF14 in bladder cancer.

Feb 8, 2025 · Data indicate taht tumor necrosis factor receptor superfamily member 14 (TNFRSF14)participated in ovariectomy (OVX)-induced adipose tissue (AT) inflammation via upregulation of CD11c, resulting in metabolic perturbation.

Feb 5, 2024 · Clinical resource with information about TNFRSF14, Common variants at CD40 and other loci confer risk of rheumatoid arthritis., Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci., Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease., Meta-analysis identifies ...

Sep 24, 2012 · TNFRSF14, or HVEM, activates NF-kappa-B (see 164011) through the canonical TNF-related cytokine LIGHT (TNFSF14; 604520), serving as a costimulatory pathway during activation of T cells.