Death receptor 5 (DR5), also known as TRAIL receptor 2 (TRAILR2) and tumor necrosis factor receptor superfamily member 10B (TNFRSF10B), is a cell surface receptor of the TNF-receptor superfamily that binds TRAIL and mediates apoptosis.

Mar 30, 2025 · TNFRSF10B (TNF Receptor Superfamily Member 10b) is a Protein Coding gene. Diseases associated with TNFRSF10B include Squamous Cell Carcinoma, Head And Neck and Laryngeal Squamous Cell Carcinoma. Among its related pathways are Dimerization of procaspase-8 and Gene expression (Transcription).

Death agonist antibody against TRAILR2/DR5/TNFRSF10B enhances birinapant anti-tumor activity in HPV-positive head and neck squamous cell carcinomas. Soluble Fas ligand drives autoantibody-induced arthritis by binding to DR5/TRAIL-R2.

Feb 8, 2025 · Title: TNFRSF10B is involved in motor dysfunction in Parkinson's disease by regulating exosomal α-synuclein secretion from microglia. Inhibition of USP1 enhances anticancer drugs-induced cancer cell death through downregulation of survivin and miR-216a-5p-mediated upregulation of DR5.

The TNF receptor family encoding genes FAS, TNFRSF10A, TNFRSF10B, TNFRSF10C and TNFRSF10D are direct p53 target genes that become up-regulated in response to p53 signaling. Thus, p53 induces the expression of death receptors that …

TNFRSF10B; TNF receptor superfamily member 10b. Aliases: DR5, CD262, KILLER, TRICK2, TRICKB, ZTNFR9, TRAILR2, TRICK2A, TRICK2B, TRAIL-R2, KILLER/DR5. Location: 8p21.3. Summary: The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain.

Jun 1, 2013 · TNFRSF10B, a tumor suppressor gene mapped on chromosome 8. Mutation in candidate gene is responsible for the loss of chromosome p arm which is frequently observed in head and neck tumors. TNFRSF10B inhibits tumor formation through apoptosis but deregulation encourages metastasis, migration and invasion of tumor cell tissues.

Clinical resource with information about TNFRSF10B, Squamous cell carcinoma of the head and neck, and available tests. There are links to practice guidelines and authoritative resources like GeneReviews, PubMed, MedlinePlus, PharmGKB and clinicaltrials.gov.

Chromosome 8: 22,877,646-22,926,692 reverse strand. This gene has 9 transcripts (splice variants), 3 paralogues and is associated with 8 phenotypes. Sorry, the page request "/Homo_sapiens/Component/Gene/Summary/gene_summary?db=core;g=ENSG00000120889;r=8:22877646-22926692;time=1732900897455.455" failed to load.

Two TNFRSF10B monomers interact with a UL141 homodimer. Three TNFRSF10B molecules interact with TNFSF10 homotrimer (PubMed: 10549288). In the absence of stimulation, interacts with BIRC2, DDX3X and GSK3B.