TNF receptor superfamily - Wikipedia
The tumor necrosis factor receptor superfamily (TNFRSF) is a protein superfamily of cytokine receptors characterized by the ability to bind tumor necrosis factors (TNFs) via an extracellular …
The TNF Family of Ligands and Receptors: Communication …
Jan 1, 2019 · The tumor necrosis factor (TNF) and TNF receptor (TNFR) superfamilies (TNFSF/TNFRSF) include 19 ligands and 29 receptors that play important roles in the …
On the TRAIL of Better Therapies: Understanding TNFRSF …
Tumor necrosis factor (TNF) superfamily ligands show diverse biological functions, such as the induction of apoptotic cell death or cell survival and proliferation, making them excellent …
The TNF Receptor Superfamily in Costimulating and Coinhibitory ...
Receptors in the TNFSF family activate diverse cellular functions, from production of type 1 interferons to the modulation of survival of antigen-activated T cells. Here, we focus attention …
Structural principles of tumor necrosis factor superfamily signaling
Tumor necrosis factor (TNF) superfamily pathways regulate cell proliferation, cell death, and morphogenesis. TNF superfamily receptors mediate various cancers and immune-mediated …
Binding Studies of TNF Receptor Superfamily (TNFRSF) Receptors …
The TNFRSF receptors are characterized by the presence of one or more copies of a conserved cysteine-rich domain in the N-terminal part of these molecules (1, 2). According to structural …
Targeting the TNF and TNFR superfamilies in autoimmune disease …
Oct 24, 2024 · Here, we provide an overview of the past and current clinical trials targeting individual TNFSF or TNFRSF members in autoimmune and inflammatory disease and cancer. …
Clinical targeting of the TNF and TNFR superfamilies - Nature
Jan 21, 2013 · TNF receptor superfamily (TNFRSF) molecules contain variable numbers of cysteine-rich domains in their ligand-binding extracellular regions (ectodomains).
Tumor necrosis factor superfamily signaling: life and death in cancer
Oct 4, 2024 · In this review, we highlight the cancer-relevant TNFSF/TNFRSF family members, focusing on the death domain-containing and co-stimulation members and their signaling …
Editorial: TNFRSF agonists: mode of action and therapeutic ...
Nov 7, 2023 · The receptors of the tumor necrosis factor (TNF) receptor superfamily (TNFRSF) fulfill crucial and manifold immunomodulatory functions and are involved in maintenance of …