Jul 28, 2020 · Strong alikeness in TMTV was found for 2.5 under software choice. Best accuracy in contouring compared to visual assessment of the disease was found for BI multiple ROI and LIFEx single ROI...

Total metabolic tumor volume (TMTV), a new parameter extracted from baseline FDG-PET/CT, has been recently proposed by several groups as a prognosticator in lymphomas before first-line treatment.

TMTV was computed on baseline positron emission tomography/computed tomography using the 41% maximum standardized uptake value method; the optimal TMTV cutoff for progression-free (PFS) and overall survival (OS) was determined and confirmed by a training validation method.

Sep 3, 2024 · Total metabolic tumor volume (TMTV) is prognostic in lymphoma. However, cutoff values for risk stratification vary markedly, according to the tumor delineation method used. We aimed to create a standardized TMTV benchmark dataset allowing TMTV to be tested and applied as a reproducible biomarker.

Jun 22, 2021 · Low intratumoral T cells associated with approximately sixfold higher TMTV, and FL nodes from patients with high TMTV showed increased malignant B-cell infiltration and fewer clonally expanded intratumoral CD8 + and CD4 + T-follicular helper cells …

Jan 22, 2020 · Total metabolic tumor volume (TMTV), calculated from 18 F-FDG PET/CT baseline studies, is a prognostic factor in diffuse large B-cell lymphoma (DLBCL) whose measurement requires the segmentation of all malignant foci throughout the body. No consensus currently exists regarding the most accurate approach for such segmentation.

Jun 22, 2021 · In summary, TMTV best reflects the malignant B-cell burden in FL, whereas intratumoral T cells influence SUVmax. This may contribute to the contradictory results between the prognostic role of different FDG-PET parameters, particularly between short- and long-term T-cell-depleting chemoimmunotherapeutic regimens.

Among them, TMTV 1 (AUC=0.82; 95% CI: 0.74 to 0.91), ΔTMTV 1 (AUC=0.83; 95% CI: 0.75 to 0.92) and ΔTLG 1 (AUC=0.83; 95% CI: 0.74 to 0.91) had the best performances. At PET interim 2, all the metabolic parameters had significant predictive power for 6 months PFS.

Dec 1, 2021 · Using the Youden index, the best TMTV cut-off value was 217 cm 3 for 5-year PFS, with a sensitivity of 67% and a specificity of 50% (Fig. 1).

Feb 1, 2017 · The purpose of this study was to compare in a large series of peripheral T cell lymphoma, as a model of diffuse disease, the prognostic value of baseline total metabolic tumor volume (TMTV) measured on 18F-FDG PET/CT with adaptive thresholding methods with TMTV measured with a fixed 41% SUVmax threshold method.