Trimethobenzamide (trade names Tebamide, Tigan) is an antiemetic used to prevent nausea and vomiting. Trimethobenzamide is an antagonist of the D 2 receptor. [1] . It is believed to affect the chemoreceptor trigger zone (CTZ) of the medulla oblongata to suppress nausea and vomiting.

Mar 1, 2004 · Trimethobenzamide (Tigan) The 5-HT 3 antagonists are the newest and most expensive antiemetics. The three primary agents—ondansetron (Zofran), dolasetron (Anzemet), and granisetron (Kytril ...

Trimethobenzamide is a novel antiemetic which prevents nausea and vomiting in humans. Its actions are unclear but most likely involves the chemoreceptor trigger zone (CTZ).

Several classes of antiemetic drugs are available that antagonize the neurotransmitter receptors known to be involved in the physiology of nausea and vomiting. The antiemetic drugs are classified according to their primary action; some agents affect multiple receptors.

Tigan: 100 mg/mL (20 mL) [contains phenol] Acts centrally to inhibit the medullary chemoreceptor trigger zone by blocking emetic impulses to the vomiting center. Via oxidation, forms metabolite trimethobenzamide N-oxide. Urine (30% to 50%, as unchanged drug) Oral: 10 to 40 minutes; IM: 15 to 35 minutes. Oral: ~45 minutes; IM: ~30 minutes.

Common Trade Names: Tigan; Adult Dosing Nausea/Vomiting. 200mg IM q8h prn, 300mg PO q8h prn Can be used as an antiemetic in patients with a prolonged QTc; Pediatric Dosing Nausea/Vomiting. Expert recommendations do not suggest trimethobenzamide as a therapeutic option; use has been replaced by newer agents with an improved safety profile ...

Antihistamines and anticholinergic agents are most effective in patients with nausea resulting from vestibular and central nervous system causes. Dopamine antagonists block dopamine in the...

Tigan is an antiemetic indicated in adults for the treatment of postoperative nausea and vomiting and for nausea associated with gastroenteritis. (1) Capsule: 300 mg of trimethobenzamide hydrochloride. (3) Known hypersensitivity to trimethobenzamide. (4)

Medscape - Indication-specific dosing for Tigan (trimethobenzamide), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost...

Jan 15, 2024 · Tigan (trimethobenzamide) is an antiemetic that's used to treat nausea and vomiting from a stomach flu or nausea and vomiting that happens after surgery. This medication is approved for use in adults only. It's available as a generic capsule that's taken by mouth 3 …