ANG1 is a Tie2 agonist that promotes vascular stabilization in inflammation and sepsis, whereas ANG2 is a context-dependent Tie2 agonist or antagonist. A limited understanding of ANG signaling mechanisms and the orphan receptor Tie1 has hindered development of ANG/Tie-targeted therapeutics.

Jun 15, 2023 · We analyzed functions of TIE1 as well as its synergy with TIE2 in the regulation of vein formation by employing genetic mouse models targeting Tie1, Tek, and Nr2f2, together with in vitro cultured endothelial cells to decipher the underlying mechanism.

Tie1, an endothelial specific receptor tyrosine kinase, is up-regulated by oscillating shear stress and is required for lymphatic valve development. In this study, we demonstrate that valvular endothelial Tie1 is differentially expressed in a dynamic pattern predicted by disturbed flow during valve remodeling.

Jan 13, 2022 · Tie1 is highly expressed in both human and mouse SC. Tie1 knock out mice display hypomorphic SC and elevated intraocular pressure as a result of attenuated SC development. Tie1 is indispensable for SC development and function, supporting it as a novel target for future SC-targeted glaucoma therapies and a candidate gene for glaucoma in humans.

Jun 1, 2013 · The most informative Tie1 mutant animals will be used for RNA-Seq and bioinformatic analysis for construction of signaling networks that will define a unique singling signature for Tie1 and help delineate endothelial cell autonomous and non-autonomous signaling pathways in the heart.

Apr 1, 2001 · Tie1 signal transduction has been difficult to study as no ligand for this receptor has been identified. However, recent studies indicate that Tie1 participates in ligand-independent...

ANG1 is a Tie2 agonist that promotes vascular stabilization in inflammation and sepsis, whereas ANG2 is a context-dependent Tie2 agonist or antagonist. A limited understanding of ANG signaling mechanisms and the orphan receptor Tie1 has hindered development of ANG/Tie-targeted therapeutics.

TIE1 is a cell surface protein expressed exclusively in endothelial cells, however it has also been shown to be expressed in immature hematopoietic cells [6] and platelets. [7] TIE1 upregulates the cell adhesion molecules (CAMs) VCAM-1, E-selectin, and ICAM-1 …

Jan 1, 2021 · tll1 overexpression can rescue the cardiac jelly thickness phenotype in tie1 mutants, and we observed a mislocalization of Laminin in tie1 −/− hearts (Fig. S8), suggesting that Tolloid-like 1 is an important modulator of the ECM during heart development.

Recent discoveries involving the tyrosine kinase receptor, Tie1 in (1) mechanotransduction, (2) inflammation and (3) neovascularization has invigorated these efforts. In this review, we will present the current understanding on Tie1 and its role in these key components of atherogenesis.