Thrombin (Factor IIa) (EC 3.4.21.5, fibrose, thrombase, thrombofort, topical, thrombin-C, tropostasin, activated blood-coagulation factor II, E thrombin, beta-thrombin, gamma-thrombin) is a serine protease, that converts fibrinogen into strands of insoluble fibrin, as well as catalyzing many other coagulation-related reactions.

Feb 15, 2024 · Uses of Thrombin: It is used to treat or prevent bleeding. What do I need to tell my doctor BEFORE I take Thrombin? If you are allergic to thrombin; any part of thrombin; or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had.

Thrombin is a multi-functional serine protease that converts fibrinogen to fibrin. Thrombin also activates other proteins in the coagulation cascade, such as coagulation factors V, VIII, XI, and XIII. It is also arguably the most effective agonist for platelet activation via the activation of PARs.

Thrombin performs essential functions in vertebrate biology as the central enzyme involved in blood coagulation and platelet aggregation, and as a mitogen and secretagogue for a variety of cell types.

Jan 21, 2022 · Although thrombin primarily converts fibrinogen to fibrin, it also has many other positive regulatory effects on coagulation. Thrombin has procoagulant, inflammatory, cellular proliferation and anticoagulant effects. In coagulation system, thrombin has two very distinct roles.

Thrombin is a Na+-activated, allosteric serine protease that plays opposing functional roles in blood coagulation. Binding of Na+ is the major driving force behind the procoagulant, prothrombotic and signaling functions of the enzyme, but is ...

May 22, 2023 · Thrombin is a topical hemostatic agent used to control and minimize blood loss during surgical procedures, is utilized in conjunction or as an alternative to standard surgical techniques. The Federal Drug Administration has approved three thrombin-based products: recombinant thrombin, human thrombin, and bovine thrombin.

Thrombin is a key enzyme in hemostasis and thrombosis, regulating pro‐ and anticoagulant reactions by interacting with other coagulation proteins and cellular receptors.1 Thrombin also carries out a plethora of biologically relevant actions that link to other complex biological processes such as angiogenesis, inflammation, and cell ...

Jul 1, 2011 · Thrombin begins life as an inactive zymogen, prothrombin. The conversion of prothrombin to thrombin is catalyzed by factor Xa and includes two essential proteolytic cleavages, producing three intermediates: prethrombin 2, meizothrombin, and Fragment 1.2 (F1.2), which binds ABE2.

Oct 13, 2008 · Thrombin is a serine protease of the chymotrypsin family, which includes enzymes involved in digestion and degradative processes, blood coagulation, cell-mediated immunity and cell death, complement, fibrinolysis, fertilization, and embryonic development.