Structural and functional evidence of bacterial antiphage
Jun 4, 2020 · The Thoeris defense system is a recently discovered bacterial defense system that protects bacteria against phage infection and consists of the two genes thsA and thsB.
Activation of Thoeris antiviral system via SIR2 effector filament ...
Feb 21, 2024 · In the Thoeris system, a Toll/interleukin-1 receptor (TIR)-domain protein, ThsB, acts as a sensor that synthesizes an isomer of cyclic ADP ribose, 1′′−3′ glycocyclic ADP ribose (gcADPR), which is...
Nucleotide Immune Signaling in CBASS, Pycsar, Thoeris, and …
In this article, we review the molecular mechanisms controlling nucleotide immune signaling in four major families of antiphage defense systems: CBASS, Pycsar, Thoeris, and type III CRISPR immunity.
Antiviral activity of bacterial TIR domains via immune ... - Nature
Dec 1, 2021 · TIR domains have also been shown to be involved in a bacterial anti-phage defence system called Thoeris 6, but the mechanism of Thoeris defence remained unknown. Here we show that phage...
TIR signaling activates caspase-like immunity in bacteria
Jan 30, 2025 · Together, these results demonstrate that the caspase-like protein is activated by a small molecule specifically produced by the TIR-domain protein during phage infection. We therefore name this defense system type IV Thoeris.
Structural characterization of macro domain–containing Thoeris ...
Jun 26, 2024 · Thoeris defense systems protect bacteria from infection by phages via abortive infection. In these systems, ThsB proteins serve as sensors of infection and generate signaling …
Scientists have determined the structure of the previously unknown active SIR2 effector of the bacterial defense system Thoeris (named after the Egyptian goddess who protects childbirth and...
A bacterial TIR-based immune system senses viral capsids to
Jul 29, 2024 · How bacterial TIRs recognize phage infection is not known. Here we describe the sensing mechanism for the staphylococcal Thoeris defense system, which consists of two TIR domain sensors, ThsB1 and ThsB2, and the effector ThsA.
Activation of Thoeris antiviral system via SIR2 effector filament ...
In the Thoeris system, a Toll/interleukin-1 receptor (TIR)-domain protein, ThsB, acts as a sensor that synthesizes an isomer of cyclic ADP ribose, 1''-3' glycocyclic ADP ribose (gcADPR), which is bound in the Smf/DprA-LOG (SLOG) domain of the ThsA effector and activates the silent information regulator 2 (SIR2)-domain-mediated hydrolysis of a ...
TIR signaling activates caspase-like immunity in bacteria
Oct 25, 2024 · The TIR-caspase defense system, which we denote as type IV Thoeris, is abundant in bacteria and efficiently protects against phage propagation. Our study highlights the diversity of TIR-produced immune signaling molecules and demonstrates that cell death regulated by proteases of the caspase family is an ancient mechanism of innate immunity.