In organosulfur chemistry, the thiol-ene reaction (also alkene hydrothiolation) is an organic reaction between a thiol (R−SH) and an alkene (R2C=CR2) to form a thioether (R−S−R').

Thiol-ene reactions were performed with 1.2–1.5 equivalents of thiol, significantly less than employed in the modification of 1,2-PB, at ambient temperature under UV irradiation.

Feb 17, 2010 · Herein, we review the radical-mediated thiol–ene reaction as one such click reaction. This reaction has all the desirable features of a click reaction, being highly efficient, simple to execute with no side products and proceeding rapidly to high yield.

Nov 30, 2018 · In synthetic organic chemistry, the anti-Markovnikov thiol−ene click (TEC) reaction has emerged as a powerful and widely used approach to build carbon−sulfur (C−S) bonds owing to several inherent benefits, including simple synthetic procedures, high atom economy with no side products, and easy purification, which results in the formation ...

Sep 13, 2022 · The preparation of porous polymer monoliths with dodecyl and zwitterionic functionalities via the “thiol-ene” click chemistry of thiol-containing monoliths with both hydrophobic and polar methacrylate “ene” monomers has been demonstrated.

Jan 1, 2017 · Thiol-ene polymers as promising biomedical materials. Applications in tissue engineering, drug delivery or dental restoration. Hydrogels, resins and nanoparticles by thiol-ene polymerisation. Biodegradable and potentially biocompatible thiol-ene polymers.

Jan 3, 2025 · Herein, we report a general strategy to introduce C–C, C–S–C, and functional groups into sp2-c -COFs via the thiol–ene click reaction. To demonstrate the universality of this approach, we synthesized two sp2-c COFs (COF-CN and COF-1), and subsequently introduced six different types of thiol compounds at their skeletal C═C sites.

Feb 22, 2010 · Robust, efficient, and orthogonal synthesis of dendrimers via thiol-ene "click" chemistry.

Aug 13, 2013 · Thiol‐ene photopolymerizations exhibit rapid and simplified polymerization kinetics, are relatively uninhibited by oxygen, form low stress homogeneous polymer networks, and are able to achieve a wide range of material properties. Each of these unique thiol‐ene properties will be discussed in detail.

This review highlights examples of recent applications of both the radical-mediated and base/nucleophile-initiated thiol-ene reactions in polymer and materials synthesis.