General structure of a thioester, where R and R' are organyl groups, or H in the case of R. In organic chemistry, thioesters are organosulfur compounds with the molecular structure R−C(=O)−S−R’.

May 22, 2021 · Thioesters are biologically important carboxylic acid derivatives. Acetyl coenzyme A is an important thioester in metabolism and transports two carbon atoms to the Citric Acid Cycle (Kreb's …

May 16, 2023 · The acyl group of a thioester can be transferred to a water molecule in a hydrolysis reaction, resulting in a carboxylate. An example of thioester hydrolysis is the conversion of (S)-citryl CoA to citrate in the citric acid cycle (also known as the Krebs cycle).

Sep 30, 2024 · As mentioned in the chapter introduction, the substrate for a nucleophilic acyl substitution reaction in living organisms is generally either a thioester (RCOSR′) or an acyl phosphate (RCO 2 PO 3 2 – or RCO 2 PO 3 R′ –). Neither is as reactive as an acid chloride or acid anhydride, yet both are stable enough to exist in living organisms ...

Mar 12, 2025 · Understanding thioester mechanisms provides insight into both metabolic pathways and synthetic applications. Formation Processes. Thioesters form through biochemical and synthetic pathways, leveraging the unique reactivity of sulfur-containing functional groups.

Coenzyme A, a crucial cofactor in many enzymatic reactions, contains a thioester functional group that allows it to activate and transfer acyl groups. Thioesters can be synthesized by the reaction of a carboxylic acid and a thiol, similar to the esterification reaction that produces esters.

Apr 9, 2025 · The meaning of THIOESTER is an ester formed by uniting a carboxyl group of one compound (as acetic acid) with a sulfhydryl group of another (as coenzyme A).

A thioester is a type of chemical bond formed between a carboxylic acid and a thiol group. Thioesters are formed through a reaction between a carboxylic acid and a thiol group. The thiol group, which contains a sulfur atom, replaces the hydroxyl group of the carboxylic acid, resulting in the formation of a thioester bond.

Thioesterases are a large superfamily of enzymes that play important cellular roles. They catalyse the cleavage of thioester bonds that are present in a wide range of activated fatty acyl-coenzyme A (CoA) substrates, acyl-carrier proteins (ACPs), glutathione, and other cellular molecules (Fig. 1). CoA-bound substrates are found as intermediates ...

A thioester forms when a sulfhydryl (whose general form is written as an organic group, R, bonded with sulfur and hydrogen, hence R-SH) joins with a carboxylic acid (R'-COOH). A molecule of water (H 2 O) is released in the process, and …