Nicotinic acetylcholine receptors, or nAChRs, are receptor polypeptides that respond to the neurotransmitter acetylcholine. Nicotinic receptors also respond to drugs such as the agonist nicotine. They are found in the central and peripheral nervous system, muscle, and many other tissues of many organisms.

Nicotinic acetylcholine receptors (nAChRs) belong to the “Cys-loop” superfamily of ligand-gated ion channels that includes GABAA, glycine, and serotonin (5-HT3) receptors. There are 16 homologous mammalian nAChR subunits encoded by a multigene ...

Apr 4, 2018 · The nicotinic acetylcholine receptor (nAChR) is a typical ion channel type receptor. nAChR agonists such as nicotine evoke rapid excitatory responses in order of milliseconds. In addition to acute responses, sustained stimulation of nAChRs induces delayed cellular responses leading to neuroprotection via intracellular signal pathways probably ...

The nAChR has been proposed as a model of an allosteric protein in which effects arising from the binding of a ligand to a site on the protein can lead to changes in another part of the molecule. A great deal is known about the structure of the pentameric receptor.

Nicotinic acetylcholine receptors (nAChR) are ligand-gated ion channels and occur on the body wall muscles of both vertebrates and invertebrates.

Neuronal nicotinic acetylcholine receptors (nAChRs) belong to a super-family of Cys-loop ligand-gated ion chan-nels that respond to endogenous acetylcholine (ACh) or other cholinergic ligands.

Nicotinic acetylcholine receptors (nAChRs) are cholinergic receptors which are activated by the endogenous neurotransmitter acetylcholine (1). Distinct from muscarinic acetylcholine receptors, nAChRs can also respond to nicotine, belonging to the cys-loop superfamily of receptors (2, 3).

nAChRs are the focus of intense drug discovery efforts for the treatment of several nervous-system disorders, including Alzheimer's disease, Parkinson's disease, schizophrenia, depression and...

Nov 25, 2020 · Neuronal nicotinic acetylcholine receptors (nAChRs) are prototypical cation-selective, ligand-gated ion channels that mediate fast neurotransmission in the central and peripheral nervous systems. nAChRs are involved in a range of physiological and pathological functions and hence are important therapeutic targets.

Nicotinic acetylcholine receptors (nAChRs) are integral membrane proteins and prototypic members of the ligand-gated ion-channel superfamily, which has precursors in the prokaryotic world.